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- 英文名：
BioLegend 844401 Purified (azide-free) anti-LRRK2
- 供应商：
北京云肽生物科技有限公司
BioLegend 844401 Purified (azide-free) anti-LRRK2
北京云肽生物科技有限公司作为 BioLegend 的特约经销商，为广大客户提供原装正品，货期短，折扣好的服务准则。
美国 BioLegend 公司位于美国加州，致力于为生物医药研究的各个前沿领域提供高质量的抗体及其它相关试剂。BioLegend 虽然成立的时间不长，但它聚集了一批来自 PharMingen 公司的专业人士，建立了一支具有雄厚技术背景的专业队伍。通过其自身的先天优势，以及与世界知名实验室和研究所的良好合作关系，以合理的价格为广大客户提供高质量的免疫学和细胞生物学产品。
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BioLegend 844401 Purified (azide-free) anti-LRRK2
产品简介：
产品品牌：BioLegend
产品货号：844401
产品名称：BioLegend 844401 Purified (azide-free) anti-LRRK2
产品规格：100 µL
产品说明：
Clone 8G10 (See other available formats)
Regulatory Status RUO
Other Names
Leucine-rich repeat serine/threonine-protein kinase 2, augmented in rheumatoid arthritis 17, AURA17, DARDARIN, PARK8, RIPK7, ROCO2
Previously Covance Catalog# MMS-5301
Isotype Mouse IgG1, κ
描述
富含亮氨酸的重复激酶2（LRRK2）是富含亮氨酸重复激酶家族的成员。这种蛋白质还具有GTP酶的功能。富含亮氨酸区域的蛋白质在蛋白质-蛋白质相互作用中发挥作用，并介导细胞结构框架（细胞骨架）的组装。LRRK2基因的突变与晚发性帕金森病有关。
Leucine-rich repeat kinase 2 (LRRK2), is a member of the leucine-rich repeat kinase family. This protein also functions as a GTPase. Proteins with leucine-rich regions play a role in protein-protein interactions and mediate assembly of the cell's structural framework (cytoskeleton). Mutations in LRRK2 genes have been associated with late-onset Parkinson's disease.
Product Details
Verified Reactivity Human
Antibody Type Monoclonal
Host Species Mouse
Immunogen
Antibody is against amino acids 100 - 500 of human LRRK2.
Formulation Phosphate-buffered solution.
Preparation
The antibody was purified by affinity chromatography.
Concentration 1 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C. Please note the storage condition for this antibody has been changed from -20°C to between 2°C and 8°C. You can also check your vial or your CoA to find the most accurate storage condition for this antibody.
Application WB - Quality tested
Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 1.0 - 2.0 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.
Antigen Details
Structure
This gene is a member of the leucine-rich repeat kinase family and is encoded by the PARK8 gene. The protein is present mainly in the cytoplasm but can be associated with the mitochondrial outer membrane.
Expected MW: >200 kD
Distribution
Tissue distribution: Lung, Kidney, parathyroid gland, CNS
Cellular distribution: cytoplasm, mitochondrion, nucleus, endoplasmic reticulum, lysosome, Golgi apparatus, endosome
Function
LRRK2 interacts with the C-terminal R2 RING finger domain of parkin. LRRK2 positively regulates autophagy through a calcium-dependent activation of the CaMKK/AMPK signaling pathway. Mutations in this gene have been associated with Parkinson disease.
Biology Area
Cell Biology, Mitochondrial Function, Neuroinflammation, Neuroscience, Neuroscience Cell Markers
Molecular Family Mitochondrial Markers
以下是 BioLegend 品牌部分产品，如需其他产品请联系本公司销售。
BioLegend 103006 FITC anti-mouse/human CD44 IM7 500 ug
BioLegend 103007 PE anti-mouse/human CD44 IM7 50 ug
BioLegend 103008 PE anti-mouse/human CD44 IM7 200 ug
BioLegend 103009 PE/Cyanine5 anti-mouse/human CD44 IM7 25 ug
BioLegend 103010 PE/Cyanine5 anti-mouse/human CD44 IM7 100 ug
BioLegend 103011 APC anti-mouse/human CD44 IM7 25 ug
BioLegend 103012 APC anti-mouse/human CD44 IM7 100 ug
BioLegend 103016 Alexa Fluor® 488 anti-mouse/human CD44 IM7 100 ug
BioLegend 103017 Alexa Fluor® 647 anti-mouse/human CD44 IM7 25 ug
BioLegend 103018 Alexa Fluor® 647 anti-mouse/human CD44 IM7 100 ug
BioLegend 103019 Pacific Blue™ anti-mouse/human CD44 IM7 25 ug
BioLegend 103020 Pacific Blue™ anti-mouse/human CD44 IM7 100 ug
BioLegend 103021 FITC anti-mouse/human CD44 IM7 25 tests
BioLegend 103022 FITC anti-mouse/human CD44 IM7 100 tests
BioLegend 103024 PE anti-mouse/human CD44 IM7 100 tests
BioLegend 103025 Alexa Fluor® 700 anti-mouse/human CD44 IM7 25 ug
BioLegend 103027 APC/Cyanine7 anti-mouse/human CD44 IM7 25 ug
BioLegend 103028 APC/Cyanine7 anti-mouse/human CD44 IM7 100 ug
BioLegend 103030 PE/Cyanine7 anti-mouse/human CD44 IM7 100 ug
BioLegend 103031 PerCP/Cyanine5.5 anti-mouse/human CD44 IM7 25 ug
BioLegend 103032 PerCP/Cyanine5.5 anti-mouse/human CD44 IM7 100 ug
BioLegend 103035 PerCP anti-mouse/human CD44 IM7 25 ug
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文献和实验相关实验
Cell Surface Immunofluorescence Staining Protocol
. In the mouse, purified anti-mouse CD16/CD32 antibody specific for Fcγ R III/II (BioLegend Cat. #101302, clone 93) can be used to block nonspecific staining of antibodies. In this case, block Fc receptors by pre-incubating cells with 5-10 μg/ml purified anti-CD
Phycoerythrin conjugation protocol
and Centricon concentrators. Add 0.5% sodium azide. Store at 4 °C protected from light. Do not freeze. Figure 1. Analysis of column eluate fractions from PE conjugation of monoclonal antibody IB4 (murine IgG2a, anti-human CD
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BioLegend 844401 Purified (azide-free) anti-LRRK2
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