BioLegend 825708 Alexa Fluor®

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BioLegend 825708 Alexa Fluor® 594 anti-α-Synuclein Phospho (Ser129)
产品简介：
产品品牌：BioLegend
产品货号：825708
产品名称：BioLegend 825708 Alexa Fluor® 594 anti-α-Synuclein Phospho (Ser129)
产品规格： 100 µg

产品说明：
Clone   P-syn/81A (See other available formats)
Regulatory Status   RUO
Other Names
Synuclein alpha-140, non-A4 component of amyloid, alpha-synuclein, isoform NACP140, non-A beta component of AD amyloid Parkinson disease (autosomal dominant, Lewy body) 4
Isotype   Mouse IgG2a, κ

描述
α-突触核蛋白主要在神经系统中表达，但也在其他组织中产生，包括皮肤。在大脑中，蛋白质主要是神经元，但也存在于胶质细胞中。神经元α-突触核蛋白集中在突触前神经末梢，与质膜磷脂相互作用，也存在于细胞核和线粒体中。α-突触核蛋白至少有三种异构体是通过选择性剪接产生的。最常见的同种型是140个氨基酸长的转录物。其他亚型包括缺少残基41-54的a-突触核蛋白-126；和缺乏残基103-130的α-突触核蛋白-112。α-突触核蛋白的生理作用尚不清楚，但该蛋白与调节多巴胺释放和转运、突触小泡聚集以及SNARE复合物伴侣的功能有关。α-突触核蛋白原纤维是细胞内路易体的主要成分，与帕金森病、路易体痴呆和多系统萎缩有关。α-突触核蛋白在正常生理条件下被低水平磷酸化，而大部分蛋白质在S129时在路易体中被磷酸化。
α-synuclein is expressed principally in the nervous system, but it is also produced in other tissues, including  the skin. In the brain, the protein is primarily neuronal, but it is also present in glia. Neuronal α-synuclein is concentrated in presynapt   ic nerve terminals, interacts with plasma membrane phospholipids, and is also present in nuclei and mitochondria. At least three isoforms of α-synuclein are produced through alternative splicing. The most common isoform is a 140 amino acid-long transcript. Other isoforms includes, a-synuclein-126, lacking residues 41-54; and α-synuclein-112, which lacks residues 103-130. α-synuclein’s physiological role is poorly understood, but the protein has been implicated in regulating dopamine release and transport, synaptic vesicle clustering, and functioning as a SNARE-complex chaperone. α-synuclein fibrils are a major component of the intracellular Lewy bodies that are associated with Parkinson's disease, Lewy body dementia, and multiple system atrophy. α-synuclein is phosphorylated at low levels under normal physiological conditions whereas the majority of the protein is phosphorylated in Lewy bodies at S129.

Product Details
Verified Reactivity   Human
Antibody Type   Monoclonal
Host Species   Mouse
Immunogen
This monoclonal antibody was raised against a synthetic peptide corresponding to amino acids 124 - 134 of α-synuclein, phosphorylated at Serine 129, and conjugated to KLH via a C-terminal Cysteine.

Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.

Preparation
The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 594 under optimal conditions.
Concentration    0.5 mg/ml

Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application    IHC-P - Quality tested

Recommended Usage
Each lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemistry, a concentration range of 5.0 - 10.0 µg/ml is suggested. It is recommended that the reagent be titrated for optimal performance for each application.

* Alexa Fluor® 594 has an excitation maximum of 590 nm, and a maximum emission of 617 nm.

Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.

Antigen Details
Structure
α-synuclein’s canonical isoform consists of 140 amino acids, which consist of four 11-residue repeats containing the consensus sequence KTKEGV. α-synuclein has an apparent molecular mass of 14 kD.

Distribution
Tissue distribution: primarily nervous system, but lower expression in other tissues such as skin.
Cellular distribution: cytoskeleton, cytosol, lysosome, mitochondria, nucleus, plasma membrane, and extracellular.

Function
The function of α-synuclein in the healthy brain is currently unknown.

Biology Area
Cell Biology, Neurodegeneration, Neuroscience, Protein Misfolding and Aggregation
Molecular Family   α-Synuclein, Phospho-Proteins

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