BioLegend 808201 Purified (azi

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BioLegend 808201 Purified (azide-free) anti-LRRK2
产品简介：
产品品牌：BioLegend
产品货号：808201
产品名称：BioLegend 808201 Purified (azide-free) anti-LRRK2
产品规格：100 µL

产品说明：
Clone   MC.028.83.76.242 (See other available formats)
Regulatory Status   RUO
Other Names
Leucine-rich repeat serine/threonine-protein kinase 2, augmented in rheumatoid arthritis 17, AURA17, DARDARIN, PARK8, RIPK7, ROCO2
Previously   Covance Catalog# SIG-39840
Isotype    Mouse IgG1, κ

描述
富含亮氨酸的重复激酶2（LRRK2）是富含亮氨酸重复激酶家族的成员。这种蛋白质还具有GTP酶的功能。富含亮氨酸区域的蛋白质在蛋白质-蛋白质相互作用中发挥作用，并介导细胞结构框架（细胞骨架）的组装。LRRK2基因的突变与晚发性帕金森病有关。
Leucine-rich repeat kinase 2 (LRRK2), is a member of the leucine-rich repeat kinase family. This protein also functions as a GTPase. Proteins with leucine-rich regions play a role in protein-protein interactions and mediate assembly of the cell's structural framework (cytoskeleton). Mutations in LRRK2 genes have been associated with late-onset Parkinson's disease.

Product Details
Verified Reactivity   Human
Antibody Type   Monoclonal
Host Species   Mouse
Immunogen
This monoclonal antibody was raised against a peptide immunogen comprising amino acids 2069-2087 of the LRRK2 protein in mice that did not express endogenous LRRK2 protein.

Formulation   Phosphate-buffered solution.
Preparation
The antibody was purified by affinity chromatography.
Concentration   1 mg/ml

Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C. Please note the storage condition for this antibody has been changed from -20°C to between 2°C and 8°C. You can also check your vial or your CoA to find the most accurate storage condition for this antibody.
Application    IHC-P - Quality tested
Direct ELISA - Verified

Recommended Usage
Each lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemistry, a concentration of 25 µg/mL is suggested. For Direct ELISA, a concentration range of 1.0 - 10 µg/mL is suggested. It is recommended that the reagent be titrated for optimal performance for each application.

Antigen Details
Structure
This gene is a member of the leucine-rich repeat kinase family and is encoded by the PARK8 gene. The protein is present mainly in the cytoplasm but can be associated with the mitochondrial outer membrane.

Distribution
Tissue distribution: Lung, Kidney, parathyroid gland, CNS
Cellular distribution: cytoplasm, mitochondrion, nucleus, endoplasmic reticulum, lysosome, Golgi apparatus, endosome

Function
LRRK2 interacts with the C-terminal R2 RING finger domain of parkin. LRRK2 positively regulates autophagy through a calcium-dependent activation of the CaMKK/AMPK signaling pathway. Mutations in this gene have been associated with Parkinson disease.

Biology Area
Cell Biology, Mitochondrial Function, Neuroinflammation, Neuroscience, Neuroscience Cell Markers
Molecular Family    Mitochondrial Markers

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