BioLegend 694404 Ultra-LEAF™ P

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BioLegend 694404 Ultra-LEAF™ Purified anti-human CCL22
产品简介：
产品品牌：BioLegend
产品货号：694404
产品名称：BioLegend 694404 Ultra-LEAF™ Purified anti-human CCL22
产品规格：1 mg

产品说明：
Clone   A15083D (See other available formats)
Regulatory Status   RUO
Other Names
Macrophage derived cytokine (MDC), Small inducible cytokine subfamily A, member 22 (Scya22), stimulated T cell chemotactic protein (STCP-1)
Isotype   Mouse IgG2a, κ

描述
CCL22是参与T细胞募集的胸腺特异性趋化因子。CCL22与不同的疾病有关，如过敏原引起的肺部炎症、特应性皮炎和淋巴瘤。此外，在多发性硬化症（MS）和实验性自身免疫性脑脊髓炎（EAE）的中枢神经系统中检测到高水平的CCL22。此外，CCR4+T细胞与内毒素休克、类风湿性关节炎、T细胞淋巴瘤和自身免疫性糖尿病有关。CCL22是一种前列腺素依赖性热原，作用于下丘脑前部，通过激活棕色脂肪组织诱导高温。
CCL22 is thymus-specific chemokine engaged in the recruitment of T cells. CCL22 is associated with different diseases such as allergen-induced lung inflammation, atopic dermatitis, and lymphoma. Also, high levels of CCL22 have been detected in the CNS in multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE). In addition, CCR4+ T cells have been linked to endotoxic shock, rheumatoid arthritis, T cell lymphoma, and autoimmune diabetes. CCL22 is a prostaglandin-dependent pyrogen, acting in the anterior hypothalamus to induce hyperthermia via activation of brown adipose tissue.

Product Details
Verified Reactivity   Human
Antibody Type   Monoclonal
Host Species   Mouse
Immunogen   Human CCL22
Formulation
0.2 µm filtered in phosphate-buffered solution, pH 7.2, containing no preservative. Endotoxin level is <0.01 EU/µg of the protein (<0.001 ng/µg of the protein) as determined by the LAL test.

Preparation
The Ultra-LEAF™ (Low Endotoxin, Azide-Free) antibody was purified by affinity chromatography.

Concentration
The antibody is bottled at the concentration indicated on the vial, typically between 2 mg/mL and 3 mg/mL. Older lots may have also been bottled at 1 mg/mL. To obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.

Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C. This Ultra-LEAF™ solution contains no preservative; handle under aseptic conditions.
Application   Neut - Quality tested

Recommended Usage
Each lot of this antibody is quality control tested by neutralizing activity. The ND50 is 1.5 - 4.5 µg/mL. It is recommended that the reagent be titrated for optimal performance for each application.

Antigen Details
Structure   Chemokine
Distribution
Macrophages, NK cells, IFN-γ stimulated human keratinocytes, thymic epithelial cells, and intestinal epithelial cells

Function
CCL22 induces the migration of CCR4+ Th2 cells, Tregs, DC, and NK cells. It is induced by LPS and CD40 antibody in macrophages. It is upregulated by Th2 cytokines (IL-4 and IL-5) and downregulated by Th1 cytokines (IFN-γ).

Interaction
Dendritic cells, NK cells, Th2 cells, T regs, CLA+ skin-homing memory/effector T cells
Ligand/Receptor    CCR4
Biology Area    Cell Biology, Signal Transduction
Molecular Family    Cytokines/Chemokines

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