产品说明: Clone A15083D (See other available formats) Regulatory Status RUO Other Names Macrophage derived cytokine (MDC), Small inducible cytokine subfamily A, member 22 (Scya22), stimulated T cell chemotactic protein (STCP-1) Isotype Mouse IgG2a, κ
描述 CCL22是参与T细胞募集的胸腺特异性趋化因子。CCL22与不同的疾病有关,如过敏原引起的肺部炎症、特应性皮炎和淋巴瘤。此外,在多发性硬化症(MS)和实验性自身免疫性脑脊髓炎(EAE)的中枢神经系统中检测到高水平的CCL22。此外,CCR4+T细胞与内毒素休克、类风湿性关节炎、T细胞淋巴瘤和自身免疫性糖尿病有关。CCL22是一种前列腺素依赖性热原,作用于下丘脑前部,通过激活棕色脂肪组织诱导高温。 CCL22 is thymus-specific chemokine engaged in the recruitment of T cells. CCL22 is associated with different diseases such as allergen-induced lung inflammation, atopic dermatitis, and lymphoma. Also, high levels of CCL22 have been detected in the CNS in multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE). In addition, CCR4+ T cells have been linked to endotoxic shock, rheumatoid arthritis, T cell lymphoma, and autoimmune diabetes. CCL22 is a prostaglandin-dependent pyrogen, acting in the anterior hypothalamus to induce hyperthermia via activation of brown adipose tissue.
Product Details Verified Reactivity Human Antibody Type Monoclonal Host Species Mouse Immunogen Human CCL22 Formulation 0.2 µm filtered in phosphate-buffered solution, pH 7.2, containing no preservative. Endotoxin level is <0.01 EU/µg of the protein (<0.001 ng/µg of the protein) as determined by the LAL test.
Preparation The Ultra-LEAF™ (Low Endotoxin, Azide-Free) antibody was purified by affinity chromatography.
Concentration The antibody is bottled at the concentration indicated on the vial, typically between 2 mg/mL and 3 mg/mL. Older lots may have also been bottled at 1 mg/mL. To obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.
Storage & Handling The antibody solution should be stored undiluted between 2°C and 8°C. This Ultra-LEAF™ solution contains no preservative; handle under aseptic conditions. Application Neut - Quality tested
Recommended Usage Each lot of this antibody is quality control tested by neutralizing activity. The ND50 is 1.5 - 4.5 µg/mL. It is recommended that the reagent be titrated for optimal performance for each application.
Antigen Details Structure Chemokine Distribution Macrophages, NK cells, IFN-γ stimulated human keratinocytes, thymic epithelial cells, and intestinal epithelial cells
Function CCL22 induces the migration of CCR4+ Th2 cells, Tregs, DC, and NK cells. It is induced by LPS and CD40 antibody in macrophages. It is upregulated by Th2 cytokines (IL-4 and IL-5) and downregulated by Th1 cytokines (IFN-γ).
Interaction Dendritic cells, NK cells, Th2 cells, T regs, CLA+ skin-homing memory/effector T cells Ligand/Receptor CCR4 Biology Area Cell Biology, Signal Transduction Molecular Family Cytokines/Chemokines
以下是 BioLegend 品牌部分产品,如需其他产品请联系本公司销售。 BioLegend 574004 Recombinant Human IL-4 (carrier-free) - 25 ug BioLegend 574006 Recombinant Human IL-4 (carrier-free) - 100 ug BioLegend 574102 Recombinant Human IL-23 (carrier-free) - 10 ug BioLegend 574304 Recombinant Mouse IL-4 (carrier-free) - 25 ug BioLegend 574306 Recombinant Mouse IL-4 (carrier-free) - 100 ug BioLegend 574502 Recombinant Mouse IL-21 (carrier-free) - 10 ug BioLegend 574602 Recombinant Mouse G-CSF (carrier-free) - 10 ug BioLegend 574604 Recombinant Mouse G-CSF (carrier-free) - 25 ug BioLegend 574802 Recombinant Human M-CSF (carrier-free) - 10 ug BioLegend 574804 Recombinant Human M-CSF (carrier-free) - 25 ug BioLegend 574806 Recombinant Human M-CSF (carrier-free) - 100 ug BioLegend 575102 Recombinant Mouse IL-1β (carrier-free) - 10 ug BioLegend 575106 Recombinant Mouse IL-1β (carrier-free) - 100 ug BioLegend 575106 Recombinant Mouse IL-1β (carrier-free) - 100 ug BioLegend 575109 Recombinant Mouse IL-1β (ELISA Std.) - 4 pack BioLegend 575202 Recombinant Mouse TNF-α (carrier-free) - 10 ug BioLegend 575204 Recombinant Mouse TNF-α (carrier-free) - 25 ug BioLegend 575206 Recombinant Mouse TNF-α (carrier-free) - 100 ug BioLegend 575302 Recombinant Mouse IFN-γ (carrier-free) - 10 ug BioLegend 575304 Recombinant Mouse IFN-γ (carrier-free) - 25 ug BioLegend 575402 Recombinant Mouse IL-2 (carrier-free) - 10 ug BioLegend 575406 Recombinant Mouse IL-2 (carrier-free) - 100 ug