BioLegend 662412 PE anti-IκB-α

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BioLegend 662412 PE anti-IκB-α
产品简介：
产品品牌：BioLegend
产品货号：662412
产品名称：BioLegend 662412 PE anti-IκB-α
产品规格：100 tests

产品说明：
Clone   3D6C02 (See other available formats)
Regulatory Status   RUO
Other Names
Nuclear factor of kappa light chain enhancer in B cells-inhibitor alpha, IKBA
Isotype   Mouse IgG2b, κ

描述
IκB-α是一种与NF-κB复合物结合的抑制性蛋白，并将该复合物保留在细胞质中，在细胞质中它不能激活转录。在细胞刺激下，IκB蛋白通过泛素途径磷酸化和降解，从而实现NF-κB的核转位。NF-κB复合物可以结合DNA，激活参与炎症、细胞增殖、分化和凋亡的多种蛋白质的基因表达。
IκB-α is an inhibitory protein that binds to the NF-κB complex and retains this complex in the cytoplasm where it cannot activate transcription. Upon cellular stimulation, the IκB proteins are phosphorylated and degraded via the ubiquitin pathway allowing for nuclear translocation of NF-κB. The NF-κB complex can then bind DNA to activate gene expression of multiple proteins involved in inflammation, cellular proliferation, differentiation, and apoptosis.

Product Details
Isotype Control   PE Mouse IgG2b, κ Isotype Ctrl
Verified Reactivity   Human, Hamster
Antibody Type   Monoclonal
Host Species   Mouse
Immunogen
Full length human IκB-α recombinant protein expressed in E. coli.
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)

Preparation
The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.

Concentration
Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)

Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application   ICFC - Quality tested

Recommended Usage
Each lot of this antibody is quality control tested by intracellular flow cytometry using our True-Phos™ Perm Buffer in Cell Suspensions Protocol. For flow cytometric staining, the suggested use of this reagent is ≤ 0.0075 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Antigen Details
Structure
Inhibitory protein of the NF-κB complex that contains multiple ankyrin repeats.
Distribution   Cytoplasm

Function
Regulates transcriptional activity of NF-κB by binding the complex and trapping it in the cytoplasm. Serine phosphorylation of IκB targets it for destruction via the ubiquitination pathway, which allows the NF-κB complex to translocate to the nucleus.

Interaction   NFkB1, SUMO4, p53, ribosomal S6 kinase 1
Biology Area
Apoptosis/Tumor Suppressors/Cell Death, Cell Biology, Signal Transduction
Molecular Family    Tumor Suppressors

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