BioLegend 329221 APC/Cyanine7

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BioLegend 329221 APC/Cyanine7 anti-human CD200 (OX2)
产品简介：
产品品牌：BioLegend
产品货号：329221
产品名称：BioLegend 329221 APC/Cyanine7 anti-human CD200 (OX2)
产品规格：100 tests

产品说明：
Clone  OX-104 (See other available formats)
Regulatory Status  RUO
Workshop  VII 70655
Other Names  OX-2, OX2
Isotype  Mouse IgG1, κ

描述
CD200，也称为OX2，是免疫球蛋白超家族（IgSF）的成员。它是一种单形态细胞表面糖蛋白，在所有淋巴器官的胸腺细胞、神经元、内皮、滤泡树突状细胞、CD34+祖细胞亚群上表达，在一些平滑肌和B淋巴细胞上低水平表达。它在NK细胞、单核细胞、粒细胞或血小板上不表达。CD200共刺激T细胞增殖。它可以调节多种组织中的髓细胞活性。CD200（OX2）和CD200受体（OX2R）系统之间的相互作用在控制巨噬细胞和粒细胞活化中具有重要意义，这可能有助于抑制和限制巨噬细胞诱导的组织炎症损伤的途径。
CD200, also known as OX2, is a member of the immunoglobulin superfamily (IgSF). It is a monomorphic cell surface glycoprotein that is expressed on thymocytes, neurons, endothelium, follicular dendritic cells in all lymphoid organs, a subset of CD34+ progenitor cells, and at low levels on some smooth muscle and B lymphocytes. It is not expressed on NK cells, monocytes, granulocytes, or platelets. CD200 costimulates T cell proliferation. It may regulate myeloid cell activity in a variety of tissues. The interaction between CD200 (OX2) and CD200 receptor (OX2R) system is of importance in the control of macrophage and granulocyte activation, which may contribute to pathways that suppress and limit macrophage induced inflammatory damage in tissue.

Product Details
Isotype Control  APC/Cyanine7 Mouse IgG1, κ Isotype Ctrl
Verified Reactivity  Human
Reported Reactivity  African Green, Baboon
Antibody Type  Monoclonal
Host Species  Mouse
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)

Preparation
The antibody was purified by affinity chromatography and conjugated with APC/Cyanine7 under optimal conditions.

Concentration
Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)

Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application  FC - Quality tested

Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

Excitation Laser  Red Laser (633 nm)
Application Notes
Additional reported applications (for the relevant formats) include: immunohistochemistry of formalin-fixed paraffin-embedded sections1 and *-fixed frozen sections2, and blocking of CD200 interaction with CD200R.

Additional Product Notes
BioLegend is in the process of converting the name APC/Cy7 to APC/Cyanine7. The dye molecule remains the same, so you should expect the same quality and performance from our APC/Cyanine7 products. Please contact Technical Service if you have any questions.

Antigen Details
Structure  Immunoglobulin superfamily
Distribution  T cells, neurons, endothelium
Function   Costimulates T cell proliferation
Receptors   CD200R
Cell Type  Endothelial cells, Neurons, T cells
Biology Area
Cell Biology, Costimulatory Molecules, Immunology, Neuroscience, Neuroscience Cell Markers
Molecular Family  CD Molecules

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