BioLegend 333628 Brilliant Vio

北京云肽生物科技有限公司作为 BioLegend 的特约经销商，为广大客户提供原装正品，货期短，折扣好的服务准则。

美国 BioLegend 公司位于美国加州，致力于为生物医药研究的各个前沿领域提供高质量的抗体及其它相关试剂。BioLegend 虽然成立的时间不长，但它聚集了一批来自 PharMingen 公司的专业人士，建立了一支具有雄厚技术背景的专业队伍。通过其自身的先天优势，以及与世界知名实验室和研究所的良好合作关系，以合理的价格为广大客户提供高质量的免疫学和细胞生物学产品。
BioLegend 公司以其专业技术力量为保证，提供各种质量卓越的产品，并不断地开发新产品，以满足飞速发展的生命科学研究的需要。

BioLegend 333628 Brilliant Violet 510™ anti-human CD163
产品简介：
产品品牌：BioLegend
产品货号：333628
产品名称：BioLegend 333628 Brilliant Violet 510™ anti-human CD163
产品规格：100 tests

产品说明：
Clone  GHI/61 (See other available formats)
Regulatory Status  RUO
Workshop  VI M38
Other Names
GHI/61, M130, RM3/1, p155, Hemoglobin/Haptoglobin Complex Receptor, macrophage-associated antigen, ED2(rat)
Isotype  Mouse IgG1, κ

描述
CD163 是 B 组清除受体富含半胱氨酸的超家族的成员，也称为 GHI/61、M130、RM3/1、p155、血红蛋白-结合珠蛋白复合物受体或巨噬细胞相关抗原。它是一种 134 kD（非还原）/155 kD（还原）糖蛋白，主要在巨噬细胞、Kupffer 细胞、单核细胞、树突状细胞亚群和造血干/祖细胞亚群上表达。CD163与结合珠蛋白-血红蛋白复合物结合并调整，并在清除血红蛋白和调节巨噬细胞产生细胞因子中发挥作用。膜CD163可以被金属蛋白酶（MMP）裂解，形成可溶性形式。血清 sCD163 水平升高与多种炎症性疾病有关。
CD163 is a member of the group B scavenger receptor cysteine-rich superfamily, also known as GHI/61, M130, RM3/1, p155, hemoglobin-haptoglobin complex receptor, or macrophage-associated antigen. It is a 134 kD (non-reduced)/155 kD (reduced) glycoprotein primarily expressed on macrophages, Kupffer cells, monocytes, a subset of dendritic cells, and a subset of hematopoietic stem/progenitor cells. CD163 binds to haptoglobin-hemoglobin complex and TWEAK, and plays a role in clearing hemoglobin and regulating cytokine production by macrophages. Membrane CD163 can be cleaved by metalloproteinases (MMP), resulting in a soluble form. Elevated serum level of sCD163 has been implicated in many kinds of inflammatory diseases.

Product Details
Isotype Control
Brilliant Violet 510™ Mouse IgG1, κ Isotype Ctrl
Verified Reactivity   Human, Cynomolgus, Rhesus
Reported Reactivity  African Green
Antibody Type  Monoclonal
Host Species  Mouse
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA).

Concentration
Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)

Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application  FC - Quality tested

Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

Brilliant Violet 510™ excites at 405 nm and emits at 510 nm. The bandpass filter 510/50 nm is recommended for detection, although filter optimization may be required depending on other fluorophores used. Be sure to verify that your cytometer configuration and software setup are appropriate for detecting this channel. Refer to your instrument manual or manufacturer for support. Brilliant Violet 510™ is a trademark of Sirigen Group Ltd.

Learn more about Brilliant Violet™.

This product is subject to proprietary rights of Sirigen Inc. and is made and sold under license from Sirigen Inc. The purchase of this product conveys to the buyer a non-transferable right to use the purchased product for research purposes only. This product may not be resold or incorporated in any manner into another product for resale. Any use for therapeutics or diagnostics is strictly prohibited. This product is covered by U.S. Patent(s), pending patent applications and foreign equivalents.
Excitation Laser   Violet Laser (405 nm)
Application Notes
Clone GHI/61 binds to domain 7 of CD163. Additional reported applications (for the relevant formats) include: immunocytochemical staining, immunoprecipitation, western blot1, and spatial biology (IBEX)6,7.

Antigen Details
Structure
134 kD (non-reduced)/155 kD (reduced) glycoprotein, scavenger receptor superfamily

Distribution
Monocytes, macrophages, Kuffer cells, subset of dendritic cells, subset of hematopoietic stem/progenitor cells

Function
Clearance of haptoglobin-hemoglobin complex, regulation of cytokine production by macrophages

Ligand/Receptor   Haptoglobin-hemoglobin complex, TWEAK
Cell Type
Dendritic cells, Hematopoietic stem and progenitors, Macrophages, Monocytes

Biology Area
Cell Biology, Immunology, Innate Immunity, Neuroscience, Neuroscience Cell Markers
Molecular Family    CD Molecules

以下是 BioLegend 品牌部分产品，如需其他产品请联系本公司销售。
BioLegend 301006 FITC anti-human CD8a    RPA-T8      100 tests
BioLegend 301007 PE anti-human CD8a  RPA-T8      25 tests
BioLegend 301010 PE/Cyanine5 anti-human CD8a   RPA-T8      100 tests
BioLegend 301012 PE/Cyanine7 anti-human CD8a   RPA-T8      100 tests
BioLegend 301014 APC anti-human CD8a     RPA-T8      100 tests
BioLegend 301015 APC/Cyanine7 anti-human CD8a      RPA-T8      25 tests
BioLegend 301016 APC/Cyanine7 anti-human CD8a      RPA-T8      100 tests
BioLegend 301021 Alexa Fluor® 488 anti-human CD8a RPA-T8      100 tests
BioLegend 301023 Pacific Blue™ anti-human CD8a  RPA-T8      100 ug
BioLegend 301030 PerCP anti-human CD8a  RPA-T8      100 tests
BioLegend 301035 Brilliant Violet 421™ anti-human CD8a   RPA-T8      25 tests
BioLegend 301036 Brilliant Violet 421™ anti-human CD8a   RPA-T8      100 tests
BioLegend 301037 Brilliant Violet 570™ anti-human CD8a   RPA-T8      25 tests
BioLegend 301038 Brilliant Violet 570™ anti-human CD8a   RPA-T8      100 tests
BioLegend 301039 Brilliant Violet 605™ anti-human CD8a   RPA-T8      25 tests
BioLegend 301042 Brilliant Violet 650™ anti-human CD8a   RPA-T8      100 tests
BioLegend 301044 Brilliant Violet 711™ anti-human CD8a   RPA-T8      100 tests
BioLegend 301049 APC anti-human CD8a     RPA-T8      500 tests
BioLegend 301051 PE anti-human CD8a  RPA-T8      500 tests
BioLegend 301053 Purified anti-human CD8a (Maxpar® Ready)     RPA-T8      100 ug
BioLegend 301060 FITC anti-human CD8a    RPA-T8      100 ug
BioLegend 301074 Ultra-LEAF™ Purified anti-human CD8a  RPA-T8      1 mg