BioLegend 315804 FITC anti-hum

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BioLegend 315804 FITC anti-human CD177
产品简介：
产品品牌：BioLegend
产品货号：315804
产品名称：BioLegend 315804 FITC anti-human CD177
产品规格：100 tests

产品说明：
Clone  MEM-166 (See other available formats)
Regulatory Status  RUO
Workshop  HCDM listed
Other Names
Neutrophil specific antigen 1, NB1, polycythemia rubra vera 1
Isotype  Mouse IgG1, κ

描述
CD177 也称为中性粒细胞特异性抗原 1、NB1 和真性红细胞增多症 1。它是uPAR家族的成员，是一种分子量为60kD的GPI连接的细胞表面糖蛋白。CD177在粒细胞和骨髓祖细胞（早期成红细胞，巨核细胞）上表达。它被认为参与对中性粒细胞的同种异体和自身免疫反应。
CD177 is also known as neutrophil specific antigen 1, NB1, and polycythemia rubra vera 1. It is a member of the uPAR family and is a GPI-linked cell surface glycoprotein with a molecular weight of 60 kD. CD177 is expressed on granulocytes and bone marrow progenitors (early erythroblasts, megakaryocytes). It is thought to be involved in allogeneic and autoimmune responses to neutrophils.

Product Details
Isotype Control  FITC Mouse IgG1, κ Isotype Ctrl
Verified Reactivity  Human, Cynomolgus, Rhesus
Antibody Type  Monoclonal
Host Species  Mouse
Immunogen  Human granulocytes
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography, and conjugated with FITC under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application  FC - Quality tested

Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

Excitation Laser  Blue Laser (488 nm)
Application Notes
Additional reported applications (for the relevant formats) include: immunoprecipitation, Western blotting5, and immunofluorescence4.

Antigen Details
Structure  uPAR family, GPI-linked cell surface glycoprotein, 60 kD
Distribution
Granulocytes, bone marrow progenitors (early erythroblasts, megakaryocytes)
Function
Antigen involved in neutrophil allo- and autoimmunity, function unknown
Modification  Glycosylated
Cell Type
Granulocytes, Hematopoietic stem and progenitors, Neutrophils
Biology Area  Immunology
Molecular Family  CD Molecules

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