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99
- 英文名：
FITC anti-human CD154
- 供应商：
北京云肽生物科技有限公司
BioLegend 310804 FITC anti-human CD154
北京云肽生物科技有限公司作为 BioLegend 的特约经销商，为广大客户提供原装正品，货期短，折扣好的服务准则。
美国 BioLegend 公司位于美国加州，致力于为生物医药研究的各个前沿领域提供高质量的抗体及其它相关试剂。BioLegend 虽然成立的时间不长，但它聚集了一批来自 PharMingen 公司的专业人士，建立了一支具有雄厚技术背景的专业队伍。通过其自身的先天优势，以及与世界知名实验室和研究所的良好合作关系，以合理的价格为广大客户提供高质量的免疫学和细胞生物学产品。
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BioLegend 310804 FITC anti-human CD154
产品简介：
产品品牌：BioLegend
产品货号：310804
产品名称：BioLegend 310804 FITC anti-human CD154
产品规格：100 tests
产品说明：
Clone 24-31 (See other available formats)
Regulatory Status RUO
Other Names CD40L, gp39, TRAP, T-BAM, TNFSF5
Isotype Mouse IgG1, κ
描述
CD154（CD40配体）也被称为CD40L，gp39，TRAP和T-BAM。CD40配体是一种32-39 kD II型跨膜糖蛋白。它是TNF超家族的成员，在活化的T细胞上表达。据报道，它对其受体CD40结合后的B细胞共刺激很重要。此外，CD40L与B细胞上的CD40结合促进免疫球蛋白的分泌和Ig同种型转换。CD40L还参与T细胞产生细胞因子的调节。
CD154 (CD40 ligand) is also known as CD40L, gp39, TRAP and T-BAM. CD40 ligand is a 32-39 kD type II transmembrane glycoprotein. It is a member of the TNF superfamily and is expressed on activated T cells. It has been reported to be important for B cell costimulation following binding of its receptor, CD40. Additionally, binding of CD40L to CD40 on B cells promotes the secretion of immunoglobulin and Ig isotype switching. CD40L is also involved in the regulation of cytokine production by T cells.
Product Details
Isotype Control FITC Mouse IgG1, κ Isotype Ctrl
Verified Reactivity Human
Reported Reactivity Cynomolgus, Rhesus
Antibody Type Monoclonal
Host Species Mouse
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography, and conjugated with FITC under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application FC - Quality tested
Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
Excitation Laser Blue Laser (488 nm)
Application Notes
Additional reported applications (for the relevant formats) include: immunofluorescence microscopy1,3 and blocking of T cell-dependent B cell differentiation1,2,4,5. The LEAF™ purified antibody (Endotoxin <0.1 EU/µg, Azide-Free, 0.2 µm filtered) is recommended for functional assays (Cat. No. 310812). For highly sensitive assays, we recommend Ultra-LEAF™ purified antibody (Cat. No. 310828) with a lower endotoxin limit than standard LEAF™ purified antibodies (Endotoxin <0.01 EU/µg).
Antigen Details
Structure
TNF superfamily, type II transmembrane glycoprotein, cleaved as soluble CD40L, 32-39 kD
Distribution Activated T cells
Function B cell costimulation
Ligand/Receptor CD40
Cell Type T cells, Tregs
Biology Area Costimulatory Molecules, Immunology
Molecular Family CD Molecules
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BioLegend 310804 FITC anti-human CD154
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