1. 00 ±0. 07,0.33±0.03,0.34±0.04 and 0. 78±0. 06.Gastrodincouldinduceapoptosisof T98GcellsbyHOTAIR,gastrodincandown-regulatetheexpressionlevelofHOTAIR.Gastrodincouldsignificantlydown-regulatedLC3- Ⅱ /LC3- ⅠandBeclin1proteinexpressionlevels,andup -regulatedp62 protein expression levels. Therewere significant differencesbetween GAS group andcontrolgroup,between GAS + HOTAIR group and GAS +Vectorgroup (P <0. 05) .Conclusion Gastrodincan regulateautophagyandpromoteapoptosisofgliomacellsthroughlongnon-codingRNAHOTAIR.
1. 00 ±0. 07,0.33±0.03,0.34±0.04 and 0. 78±0. 06.Gastrodincouldinduceapoptosisof T98GcellsbyHOTAIR,gastrodincandown-regulatetheexpressionlevelofHOTAIR.Gastrodincouldsignificantlydown-regulatedLC3- Ⅱ /LC3- ⅠandBeclin1proteinexpressionlevels,andup -regulatedp62 protein expression levels. Therewere significant differencesbetween GAS group andcontrolgroup,between GAS + HOTAIR group and GAS +Vectorgroup (P <0. 05) .Conclusion Gastrodincan regulateautophagyandpromoteapoptosisofgliomacellsthroughlongnon-codingRNAHOTAIR.