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- 详细信息
- 文献和实验
- 技术资料
- 库存：
99
- 英文名：
Spark YG™ 593 anti-mouse F4/80 Recombinant
- 供应商：
北京云肽生物科技有限公司
BioLegend 157311 Spark YG™ 593 anti-mouse F4/80 Recombinant
北京云肽生物科技有限公司作为BioLegend的特约经销商，为广大客户提供原装正品，货期短，折扣好的服务准则。
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BioLegend 157311 Spark YG™ 593 anti-mouse F4/80 Recombinant
产品简介：
产品品牌：BioLegend
产品货号：157311
产品名称：BioLegend 157311 Spark YG™ 593 anti-mouse F4/80 Recombinant
产品规格：25 µg
产品说明：
Clone QA17A29 (See other available formats)
Regulatory Status RUO
Other Names EMR1, Ly71
Isotype Mouse IgG1, κ
描述
F4/80是一种160kD的糖蛋白。其特征为表皮生长因子（EGF）-跨膜7（TM7）家族的成员。F4/80，也称为EMR1或Ly71，已被广泛用作小鼠巨噬细胞标记物，其在大多数组织巨噬细胞上表达，包括腹膜巨噬细胞、肺、肠、胸腺和脾红髓中的巨噬细胞（但不在位于脾脏T细胞区、淋巴结和派尔氏补片中的巨噬细胞上表达）、库弗细胞、郎格汉斯细胞和骨髓基质细胞。F4/80也显示在树突细胞的亚群上。F4/80的生物配体尚未鉴定，但据报道，F4/80是诱导CD8+T细胞介导的外周耐受所必需的。
F4/80 is a 160 kD glycoprotein. It is characterized as a member of the epidermal growth factor (EGF)-transmembrane 7 (TM7) family. F4/80, also known as EMR1 or Ly71, has been widely used as a murine macrophage marker, which is expressed on the majority of tissue macrophages including peritoneal macrophages, macrophages in lung, gut, thymus and red pulp of spleen (but not on the macrophages located in T cell areas of the spleen, lymph node and Peyer's patch), Kuffer cells, Langerhans cells, and bone marrow stromal cells. F4/80 has also been shown on a subset of dendritic cells. The biological ligand of F4/80 has not been identified, but it has been reported that F4/80 is required for induction of CD8+ T cells-mediated peripheral tolerance.
Product Details
Verified Reactivity Mouse
Antibody Type Recombinant
Host Species Mouse
Immunogen Murine macrophages
Formulation Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation
The antibody was purified by affinity chromatography and conjugated with Spark YG™ 593 under optimal conditions.
Concentration 0.5 mg/mL
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application FC - Quality tested
Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.
* Spark YG™ 593 has a maximum excitation of 573 nm and a maximum emission of 593 nm.
Excitation Laser
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Antigen Details
Structure
A 160 kD glycoprotein and a member of the epidermal growth factor (EGF)-transmembrane 7 (TM7) family
Distribution
Expressed on the majority of tissue macrophages
Function Required for induction of CD8+ T cells-mediated peripheral tolerance
Cell Type Macrophages, Monocytes
Biology Area Immunology, Innate Immunity
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BioLegend 157311 Spark YG™ 593 anti-mouse F4/80 Recombinant
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