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- 库存：
99
- 英文名：
Purified anti-mouse CD204
- 供应商：
北京云肽生物科技有限公司
BioLegend 676202 Purified anti-mouse CD204
北京云肽生物科技有限公司作为 BioLegend 的特约经销商，为广大客户提供原装正品，货期短，折扣好的服务准则。
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BioLegend 676202 Purified anti-mouse CD204
产品简介：
产品品牌：BioLegend
产品货号：676202
产品名称：BioLegend 676202 Purified anti-mouse CD204
产品规格：100 µg
产品说明：
Clone 7G5C33 (See other available formats)
Regulatory Status RUO
Other Names
Macrophage scavenger receptor 1 (Msr1), Scavenger receptor type A (SR-A), SRA
Isotype Rat IgG1, κ
描述
CD204，也称为清道夫受体A（SR-A）和巨噬细胞清道夫受体（MSR），是巨噬细胞和树突状细胞上表达的吞噬模式识别受体（PRR）之一。CD204最初被鉴定为一种受体，介导巨噬细胞对低密度脂蛋白（LDL）的识别和内化，并在动脉粥样硬化形成中发挥关键作用。最近的研究表明，CD204识别凋亡细胞、修饰的脂质蛋白和外源性病原体相关分子模式（PAMP），从而诱导先天免疫和炎症反应。CD204可以作为Toll样受体（如TLR3、TLR4或TLR9）的共受体，以促进促炎细胞因子的表达。CD204与阿尔茨海默病、败血症、缺血性损伤和冠状动脉疾病等多种病理过程有关。
CD204, also known as scavenger receptor A (SR-A) and the macrophage scavenger receptor (MSR), is one of the phagocytic pattern-recognition receptors (PRRs) expressed on macrophages and dendritic cells. CD204 was initially identified as a receptor mediating recognition and internalization of low-density lipoprotein (LDL) by macrophages and playing critical roles in atherogenesis. Recent studies have revealed that CD204 recognizes apoptotic cells, modified lipid proteins, and exogenous pathogen-associated molecular patterns (PAMPs), which results in the induction of innate immune and inflammatory responses. CD204 can act as a co-receptor for Toll-like receptors, such as TLR3, TLR4, or TLR9, to facilitate the expression of proinflammatory cytokines. CD204 has been implicated in several pathological processes such as Alzheimer’s disease, sepsis, ischemic injury, and coronary artery disease.
Product Details
Verified Reactivity Mouse
Antibody Type Monoclonal
Host Species Rat
Immunogen
Partial mouse CD204 recombinant protein (79-458 a.a.) expressed in 293E cells.
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration 0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application WB - Quality tested
Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.25 - 1.0 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.
Antigen Details
Structure
485 amino acids with a predicted molecular weight of 50 kD and is a single-pass type II membrane protein.
Distribution
Plasma membrane, low-density lipoprotein particle, and endocytic vesicle emmbrane.
Function
CD204, a trimeric type II integral membrane glycoprotein, is predominantly expressed on macrophages and dendritic cells. CD204 plays important roles in lipid metabolism, host defense, and inflammatory responses.
Interaction CD204 interacts with HSPA1A.
Biology Area Cell Biology, Immunology, Innate Immunity
Molecular Family CD Molecules
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BioLegend 676202 Purified anti-mouse CD204
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