BioLegend 144204 PE anti-mouse

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BioLegend 144204 PE anti-mouse/human CD207 (Langerin)
产品简介：
产品品牌：BioLegend
产品货号：144204
产品名称：BioLegend 144204 PE anti-mouse/human CD207 (Langerin)
产品规格：100 µg

产品说明：
Clone  4C7 (See other available formats)
Regulatory Status  RUO
Other Names  CLEC4K
Isotype  Mouse IgG2a, κ

描述
CD207，也称为langerin，是一种40kD的单程II型跨膜蛋白，属于C型凝集素家族。CD207在Langerhans细胞的细胞表面和Birbeck颗粒（BG）以及胸腺和脾脏树突状细胞的亚群上表达。它的配体是甘露糖、n-乙酰葡糖胺、岩藻糖和硫酸聚糖。Langerin通过捕获和内化其配体参与抗原处理途径。
CD207, also known as langerin, is a 40 kD single-pass type II transmembrane protein, member of the C-type lectin family. CD207 is expressed on the cell surface and Birbeck granules (BGs) of Langerhans cells, and subsets of thymic and splenic dendritic cells. Its ligands are mannose, n-acetylglucosamine, fucose, and sulfated glycans. Langerin is involved in the antigen processing pathway through capture and internalization of its ligands.

Product Details
Isotype Control  PE Mouse IgG2a, κ Isotype Ctrl
Verified Reactivity  Mouse, Human
Reported Reactivity  Cynomolgus, Rabbit, Pig
Antibody Type  Monoclonal
Host Species  Mouse
Immunogen  Langerin extracellular domain-Fc fusion protein
Formulation  Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.
Concentration  0.2 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application  FC - Quality tested
IHC - Verified

Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume.  It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser  Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)

Antigen Details
Structure
Single-pass type II transmembrane protein, 40 kD, one C-type lectin domain, homotrimer
Distribution
Langerhans cells, subsets of thymic and splenic dendritic cells

Function  Antigen uptake, antigen processing
Ligand/Receptor
Mannose, n-acetylglucosamine, fucose, sulfated glycans
Cell Type  Dendritic cells, Langerhans cells
Biology Area  Immunology, Innate Immunity
Molecular Family  CD Molecules

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