BioLegend 326511 PerCP/Cyanine

北京云肽生物科技有限公司作为 BioLegend 的特约经销商，为广大客户提供原装正品，货期短，折扣好的服务准则。

美国 BioLegend 公司位于美国加州，致力于为生物医药研究的各个前沿领域提供高质量的抗体及其它相关试剂。BioLegend 虽然成立的时间不长，但它聚集了一批来自 PharMingen 公司的专业人士，建立了一支具有雄厚技术背景的专业队伍。通过其自身的先天优势，以及与世界知名实验室和研究所的良好合作关系，以合理的价格为广大客户提供高质量的免疫学和细胞生物学产品。
BioLegend 公司以其专业技术力量为保证，提供各种质量卓越的产品，并不断地开发新产品，以满足飞速发展的生命科学研究的需要。

BioLegend 326511 PerCP/Cyanine5.5 anti-human CD163
产品简介：
产品品牌：BioLegend
产品货号：326511
产品名称：BioLegend 326511 PerCP/Cyanine5.5 anti-human CD163
产品规格：25 tests

产品说明：
Clone  RM3/1 (See other available formats)
Regulatory Status  RUO
Other Names
GHI/61, M130, RM3/1, p155, Hemoglobin/haptoglobin complex receptor, Macrophage-associated antigen, ED2(rat), Macrophage marker
Isotype  Mouse IgG1, κ

描述
CD163 是 B 组清除受体富含半胱氨酸的超家族的成员，也称为 GHI/61、M130、RM3/1、p155、血红蛋白-结合珠蛋白复合物受体或巨噬细胞相关抗原。它是一种 134 kD（非还原）/155 kD（还原）糖蛋白，主要在巨噬细胞、Kuffer 细胞、单核细胞、树突状细胞亚群和造血干/祖细胞亚群上表达。CD163与结合珠蛋白-血红蛋白复合物结合并调整，并在清除血红蛋白和调节巨噬细胞产生细胞因子中发挥作用。膜CD163可以被金属蛋白酶（MMP）裂解，形成可溶性形式。血清sCD163水平升高与多种炎症性疾病有关。
CD163 is a member of the group B scavenger receptor cysteine-rich superfamily, also known as GHI/61, M130, RM3/1, p155, hemoglobin-haptoglobin complex receptor, or macrophage-associated antigen. It is a 134 kD (non-reduced)/155 kD (reduced) glycoprotein primarily expressed on macrophages, Kuffer cells, monocytes, subset of dendritic cells, and a subset of hematopoietic stem/progenitor cells. CD163 binds to haptoglobin-hemoglobin complex and TWEAK, and plays a role in clearing hemoglobin and regulating cytokine production by macrophages. Membrane CD163 can be cleaved by metalloproteinases (MMP), resulting in a soluble form. Elevated serum level of sCD163 has been implicated in many kinds of inflammation diseases.

Product Details
Isotype Control   PerCP/Cyanine5.5 Mouse IgG1, κ Isotype Ctrl
Verified Reactivity   Human
Antibody Type   Monoclonal
Host Species   Mouse
Immunogen   Human monocytes
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)

Preparation
The antibody was purified by affinity chromatography and conjugated with PerCP/Cyanine5.5 under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application  FC - Quality tested

Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

* PerCP/Cyanine5.5 has a maximum absorption of 482 nm and a maximum emission of 690 nm.

Excitation Laser  Blue Laser (488 nm)
Application Notes
Clone RM3/1 binds to domain 9 of CD163. Additional reported applications (for the relevant formats) include: immunofluorescence7.

Additional Product Notes
BioLegend is in the process of converting the name PerCP/Cy5.5 to PerCP/Cyanine5.5. The dye molecule remains the same, so you should expect the same quality and performance from our PerCP/Cyanine5.5 products. Contact Technical Service if you have any questions.

Antigen Details
Structure
134 kD (non-reduced)/155 kD (reduced) glycoprotein, Scavenger receptor superfamily
Distribution
Monocytes, macrophages, Kuffer cells, subset of dendritic cells, subset of hematopoietic stem/progenitor cells

Function
Clearance of haptoglobin-hemoglobin complex, regulation of cytokine production by macrophages
Ligand/Receptor  Haptoglobin-hemoglobin complex, TWEAK
Cell Type
Dendritic cells, Hematopoietic stem and progenitors, Macrophages, Monocytes
Biology Area
Cell Biology, Immunology, Neuroscience, Neuroscience Cell Markers
Molecular Family  CD Molecules

以下是 BioLegend 品牌部分产品，如需其他产品请联系本公司销售。
BioLegend 205405 FITC anti-rat RT1D      OX-17  100 ug
BioLegend 205505 FITC anti-rat CD103 (αE Integrin) OX-62  100 ug
BioLegend 205604 PE anti-rat CD161 3.2.3    100 ug
BioLegend 250503 FITC anti-rat CD38     14.27   50 ug
BioLegend 250604 APC anti-Baculovirus envelope gp64 AcV1   100 ug
BioLegend 250606 PE anti-Baculovirus envelope gp64   AcV1   100 ug
BioLegend 250805 FITC anti-rat CD335 (NKp46)  WEN23      25 ug
BioLegend 280007 Flex-T™ HLA-A*11:01 Monomer UVX      -    50 ug
BioLegend 280011 Flex-T™ HLA-B*08:01 Monomer UVX      -    50 ug
BioLegend 280061 Flex-T™ Biotin H-2 K(b) TRP2 Monomer (SVYDFFVWL)  -    25 ug
BioLegend 280302 Purified Streptavidin   -    250 ug
BioLegend 280303 HRP anti-human β2-microglobulin   2M2    50 ug
BioLegend 300103 FITC anti-human CD1a    HI149  25 tests
BioLegend 300106 PE anti-human CD1a  HI149  100 tests
BioLegend 300110 APC anti-human CD1a     HI149  100 tests
BioLegend 300122 PE/Cyanine7 anti-human CD1a   HI149  100 tests
BioLegend 300206 FITC anti-human CD2 RPA-2.10   100 tests
BioLegend 300208 PE anti-human CD2   RPA-2.10   100 tests
BioLegend 300210 PE/Cyanine5 anti-human CD2     RPA-2.10   100 tests
BioLegend 300213 APC anti-human CD2 RPA-2.10   25 tests
BioLegend 300214 APC anti-human CD2 RPA-2.10   100 tests
BioLegend 300218 Brilliant Violet 510™ anti-human CD2     RPA-2.10   100 tests