产品说明: Clone 2.11 (See other available formats) Regulatory Status RUO Other Names T cell receptor Vgamma 1.1, TCR Vγ1, TCR Cr4 Isotype Armenian Hamster IgG
描述 T细胞受体(TCR)是一种由α和β链(TCRα/β)或γ和δ链(TCRγ/δ)组成的异二聚体。TCR与CD3结合形成CD3/TCR复合物。CD3/TCR在抗原识别、信号转导和T细胞活化中起着关键作用。TCR Vγ1.1(Garman命名法)也称为TCR V伽马1(通川命名法)。γ1基因几乎完全重排为Jγ4-Cγ4基因。在成年小鼠的胸腺和外周淋巴器官中,表达Vγ1-Jγ4-Cγ4的细胞构成了γ/δT细胞的主要群体,但在胎儿和出生后早期,它们仅由少量γ/ΔT细胞组成。γ1 T细胞的发育可以以胸腺依赖和胸腺非依赖的方式发生。进一步的研究表明,抗体2.11识别的表位位于Cr4结构域。 T cell receptor (TCR) is a heterodimer consisting of an α and β chain (TCR α/β) or a γ and δ chain (TCR γ/δ). TCR associates with CD3 to form a CD3/TCR complex. The CD3/TCR plays a key role in antigen recognition, signal transduction, and T cell activation. TCR Vγ1.1 (Garman nomenclature) is also called TCR Vγ1 (Tonegawa nomenclature). The Vγ1 gene almost exclusively rearranges to the Jγ4-Cγ4 gene. Vγ1- Jγ4-Cγ4 expressing cells constitute a major population of γ/δ T cells in thymus and peripheral lymphoid organs in adult mice, but they are only composed of a minor population of γ/δ T cells during fetal and early postnatal life. Vγ1 T cell development can happen in thymus-dependent and thymus-independent manners. Further studies have shown that the antibody 2.11 recognized epitote is located in Cr4 domain.
Product Details Isotype Control Purified Armenian Hamster IgG Isotype Ctrl Verified Reactivity Mouse Antibody Type Monoclonal Host Species Armenian Hamster Immunogen T3.13.1 T-cell hybridoma cell line Formulation Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide. Preparation The antibody was purified by affinity chromatography. Concentration 0.5 mg/ml Storage & Handling The antibody solution should be stored undiluted between 2°C and 8°C. Application FC - Quality tested IP - Reported in the literature, not verified in house
Recommended Usage Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
Antigen Details Structure Ig superfamily Distribution Subset of γ/δ T-cells Function Antigen recognition Ligand/Receptor Antigen Cell Type T cells Biology Area Adaptive Immunity, Immunology Molecular Family TCRs
以下是BioLegend 品牌部分产品,如需其他产品请联系本公司销售。 BioLegend 123210 PE anti-mouse CD122 (IL-2Rβ) TM-β1 100 ug BioLegend 123211 PerCP/Cyanine5.5 anti-mouse CD122 (IL-2Rβ) TM-β1 25 ug BioLegend 123212 PerCP/Cyanine5.5 anti-mouse CD122 (IL-2Rβ) TM-β1 100 ug BioLegend 123213 APC anti-mouse CD122 (IL-2Rβ) TM-β1 25 ug BioLegend 123214 APC anti-mouse CD122 (IL-2Rβ) TM-β1 100 ug BioLegend 123215 PE/Cyanine7 anti-mouse CD122 (IL-2Rβ) TM-β1 25 ug BioLegend 123216 PE/Cyanine7 anti-mouse CD122 (IL-2Rβ) TM-β1 100 ug BioLegend 123218 PE/Dazzle™ 594 anti-mouse CD122 (IL-2Rβ) TM-β1 100 ug BioLegend 123307 FITC anti-mouse CD14 Sa14-2 50 ug BioLegend 123308 FITC anti-mouse CD14 Sa14-2 500 ug BioLegend 123309 PE anti-mouse CD14 Sa14-2 50 ug BioLegend 123310 PE anti-mouse CD14 Sa14-2 200 ug BioLegend 123311 APC anti-mouse CD14 Sa14-2 25 ug BioLegend 123312 APC anti-mouse CD14 Sa14-2 100 ug BioLegend 123314 PerCP/Cyanine5.5 anti-mouse CD14 Sa14-2 100 ug BioLegend 123316 PE/Cyanine7 anti-mouse CD14 Sa14-2 100 ug BioLegend 123317 APC/Cyanine7 anti-mouse CD14 Sa14-2 25 ug BioLegend 123318 APC/Cyanine7 anti-mouse CD14 Sa14-2 100 ug BioLegend 123407 FITC anti-mouse CD21/CD35 (CR2/CR1) 7000000000 50 ug BioLegend 123408 FITC anti-mouse CD21/CD35 (CR2/CR1) 7000000000 500 ug BioLegend 123409 PE anti-mouse CD21/CD35 (CR2/CR1) 7000000000 50 ug BioLegend 123411 APC anti-mouse CD21/CD35 (CR2/CR1) 7000000000 25 ug