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99
- 英文名：
Purified anti-mouse TCR Vγ1.1/Cr4
- 供应商：
北京云肽生物科技有限公司
BioLegend 141102 Purified anti-mouse TCR Vγ1.1/Cr4
北京云肽生物科技有限公司作为BioLegend的特约经销商，为广大客户提供原装正品，货期短，折扣好的服务准则。
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BioLegend 141102 Purified anti-mouse TCR Vγ1.1/Cr4
产品简介：
产品品牌：BioLegend
产品货号：141102
产品名称：BioLegend 141102 Purified anti-mouse TCR Vγ1.1/Cr4
产品规格：100 µg
产品说明：
Clone 2.11 (See other available formats)
Regulatory Status RUO
Other Names T cell receptor Vgamma 1.1, TCR Vγ1, TCR Cr4
Isotype Armenian Hamster IgG
描述
T细胞受体（TCR）是一种由α和β链（TCRα/β）或γ和δ链（TCRγ/δ）组成的异二聚体。TCR与CD3结合形成CD3/TCR复合物。CD3/TCR在抗原识别、信号转导和T细胞活化中起着关键作用。TCR Vγ1.1（Garman命名法）也称为TCR V伽马1（通川命名法）。γ1基因几乎完全重排为Jγ4-Cγ4基因。在成年小鼠的胸腺和外周淋巴器官中，表达Vγ1-Jγ4-Cγ4的细胞构成了γ/δT细胞的主要群体，但在胎儿和出生后早期，它们仅由少量γ/ΔT细胞组成。γ1 T细胞的发育可以以胸腺依赖和胸腺非依赖的方式发生。进一步的研究表明，抗体2.11识别的表位位于Cr4结构域。
T cell receptor (TCR) is a heterodimer consisting of an α and β chain (TCR α/β) or a γ and δ chain (TCR γ/δ). TCR associates with CD3 to form a CD3/TCR complex. The CD3/TCR plays a key role in antigen recognition, signal transduction, and T cell activation. TCR Vγ1.1 (Garman nomenclature) is also called TCR Vγ1 (Tonegawa nomenclature). The Vγ1 gene almost exclusively rearranges to the Jγ4-Cγ4 gene. Vγ1- Jγ4-Cγ4 expressing cells constitute a major population of γ/δ T cells in thymus and peripheral lymphoid organs in adult mice, but they are only composed of a minor population of γ/δ T cells during fetal and early postnatal life. Vγ1 T cell development can happen in thymus-dependent and thymus-independent manners. Further studies have shown that the antibody 2.11 recognized epitote is located in Cr4 domain.
Product Details
Isotype Control Purified Armenian Hamster IgG Isotype Ctrl
Verified Reactivity Mouse
Antibody Type Monoclonal
Host Species Armenian Hamster
Immunogen T3.13.1 T-cell hybridoma cell line
Formulation Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation The antibody was purified by affinity chromatography.
Concentration 0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application FC - Quality tested
IP - Reported in the literature, not verified in house
Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
Application Notes
Additional reported applications (for the relevant formats) include: immunoprecipitation1.
Antigen Details
Structure Ig superfamily
Distribution Subset of γ/δ T-cells
Function Antigen recognition
Ligand/Receptor Antigen
Cell Type T cells
Biology Area Adaptive Immunity, Immunology
Molecular Family TCRs
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BioLegend 141102 Purified anti-mouse TCR Vγ1.1/Cr4
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