产品说明: Clone C-11 (See other available formats) Regulatory Status RUO Other Names Cytokeratin, Keratin Isotype Mouse IgG1, κ
描述 细胞角蛋白是在许多组织中广泛表达的中间丝蛋白。这些蛋白质是细胞骨架的重要组成部分,并与许多其他蛋白质相互作用。细胞角蛋白通常在细胞质中发现,尽管一些细胞角蛋白可以在细胞核和核仁中发现。 Cytokeratins are intermediate filament proteins that are widely expressed in many tissues. These proteins are vital components of the cytoskeleton and interact with a number of other proteins. Cytokeratins are usually found in the cytoplasm,although some cytokeratins can be found in the nucleus and the nucleolus.
Product Details Verified Reactivity Human Antibody Type Monoclonal Host Species Mouse Immunogen Keratin enriched fraction from human epidermoid carcinoma.
Preparation The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 647 under optimal conditions. Concentration 0.5 mg/ml
Storage & Handling The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze. Application ICC - Quality tested ICFC - Verified SB - Reported in the literature, not verified in house
Recommended Usage Each lot of this antibody is quality control tested by immunocytochemistry. For immunocytochemistry, a concentration range of 1.0 - 5.0 μg/ml is recommended. For flow cytometric staining, the suggested use of this reagent is ≤ 0.125 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.
* Alexa Fluor® 647 has a maximum emission of 668 nm when it is excited at 633 nm / 635 nm.
Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.
Antigen Details Structure Intermediate filament protein, contains three coiled-coil domains. Cytokeratins exist as heterotetramers composed of two type I and two type II keratin subunits
Distribution Cytokeratins are widely expressed proteins usually found in the cytoplasm although some cytokeratins can also be found in the nucleus and the nucleolus
Function Intermediate filament protein involved with the cytoskeleton.
Interaction Most cytokeratins interact with a number of other proteins such as 14-3-3, EGF receptor, and many others
Biology Area Cell Biology, Cell Motility/Cytoskeleton/Structure, Neuroscience, Neuroscience Cell Markers Molecular Family Intermediate Filaments
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