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99
- 英文名：
Alexa Fluor® 647 anti-mouse CD199 (CCR9)
- 供应商：
北京云肽生物科技有限公司
BioLegend 129710 Alexa Fluor® 647 anti-mouse CD199 (CCR9)
北京云肽生物科技有限公司作为BioLegend的特约经销商，为广大客户提供原装正品，货期短，折扣好的服务准则。
美国BioLegend公司位于美国加州，致力于为生物医药研究的各个前沿领域提供高质量的抗体及其它相关试剂。BioLegend虽然成立的时间不长，但它聚集了一批来自PharMingen公司的专业人士，建立了一支具有雄厚技术背景的专业队伍。通过其自身的先天优势，以及与世界知名实验室和研究所的良好合作关系，以合理的价格为广大客户提供高质量的免疫学和细胞生物学产品。BioLegend公司以其专业技术力量为保证，提供各种质量卓越的产品，并不断地开发新产品，以满足飞速发展的生命科学研究的需要。
BioLegend 129710 Alexa Fluor® 647 anti-mouse CD199 (CCR9)
产品简介：
产品品牌：BioLegend
产品货号：129710
产品名称：BioLegend 129710 Alexa Fluor® 647 anti-mouse CD199 (CCR9)
产品规格：100 µg
产品说明：
Clone 9B1 (See other available formats)
Regulatory Status RUO
Other Names GPR 9-6, CDw199, Chemokine Receptor 9
Isotype Rat IgG2a, κ
描述
CCR9是G蛋白偶联受体家族的成员，参与胸腺中T细胞的发育和肠道相关免疫反应。小鼠CCR9在不同阶段的胸腺细胞上高度表达，并在CD4+CD8+细胞上上调。它在脾脏和淋巴结细胞中的表达水平要低得多。CCR9在上皮内和小肠γ/δT细胞上的表达已有报道。CCR9与其配体CCL25（TECK，胸腺表达的趋化因子）的相互作用可能指导胸腺中发育中的T细胞的运输和肠道特异性免疫记忆的产生。
CCR9 is a member of the G protein coupled receptor family and is involved in T cell development in the thymus and in gut-associated immune response. Mouse CCR9 is highly expressed on different stages of thymocytes and upregulated on CD4+CD8+ cells. It is expressed to a much lower level on spleen and lymph node cells. Expression of CCR9 on γ/δ T cells in the intraepithelial and small intestine has been reported. The interaction of CCR9 with its ligand CCL25 (TECK, thymus-expressed chemokine) may direct the trafficking of developing T cells in the thymus and generation of gut-specific immunological memory.
Product Details
Isotype Control Alexa Fluor® 647 Rat IgG2a, κ Isotype Ctrl
Verified Reactivity Mouse
Antibody Type Monoclonal
Host Species Rat
Formulation Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 647 under optimal conditions.
Concentration 0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application FC - Quality tested
Antigen Details
Structure
A membrane of G-protein coupled receptors and contains seven transmembrain domains. Mouse CCR9 has above 80% amino acid sequence homology with human counterpart.
Distribution CD4+CD8+ thymocytes, γ/δ T cells
Interaction CCL25
Ligand/Receptor CCL25
Cell Type T cells
Biology Area Immunology
Molecular Family CD Molecules, Cytokine/Chemokine Receptors, GPCR
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BioLegend 129710 Alexa Fluor® 647 anti-mouse CD199 (CCR9)
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