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- 文献和实验
- 技术资料
- 库存：
99
- 英文名：
PE anti-mouse CD11c
- 供应商：
北京云肽生物科技有限公司
BioLegend 117308 PE anti-mouse CD11c
北京云肽生物科技有限公司作为BioLegend的特约经销商，为广大客户提供原装正品，货期短，折扣好的服务准则。
美国BioLegend公司位于美国加州，致力于为生物医药研究的各个前沿领域提供高质量的抗体及其它相关试剂。BioLegend虽然成立的时间不长，但它聚集了一批来自PharMingen公司的专业人士，建立了一支具有雄厚技术背景的专业队伍。通过其自身的先天优势，以及与世界知名实验室和研究所的良好合作关系，以合理的价格为广大客户提供高质量的免疫学和细胞生物学产品。BioLegend公司以其专业技术力量为保证，提供各种质量卓越的产品，并不断地开发新产品，以满足飞速发展的生命科学研究的需要。
BioLegend 117308 PE anti-mouse CD11c
产品简介：
产品品牌：BioLegend
产品货号：117308
产品名称：BioLegend 117308 PE anti-mouse CD11c
产品规格：200 µg
产品说明：
Clone N418 (See other available formats)
Regulatory Status RUO
Other Names αX integrin, integrin αX chain, CR4, p150, ITGAX
Isotype Armenian Hamster IgG
描述
CD11c是一种150kD的糖蛋白，也称为αX整合素、CR4和p150。CD11c与β2整合素（CD18）形成αXβ2异二聚体。它主要在树突状细胞、NK细胞、肠上皮内淋巴细胞亚群（IEL）和一些活化的T细胞上表达。αXβ2整合素通过结合其配体iC3b、纤维蛋白原和CD54在细胞-细胞接触中发挥重要作用。
CD11c is a 150 kD glycoprotein also known as αX integrin, CR4, and p150. CD11c forms a αXβ2 heterodimer with β2 integrin (CD18). It is primarily expressed on dendritic cells, NK cells, a subset of intestinal intraepithelial lymphocytes (IEL), and some activated T cells. The αXβ2 integrin plays an important role in cell-cell contact by binding its ligands: iC3b, fibrinogen, and CD54.
Product Details
Isotype Control PE Armenian Hamster IgG Isotype Ctrl
Verified Reactivity Mouse
Antibody Type Monoclonal
Host Species Armenian Hamster
Immunogen Mouse spleen dendritic cells
Formulation Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.
Concentration 0.2 mg/ml
Storage & Handling The CD11c antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application FC - Quality tested
Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per 106 cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for other applications.
Excitation Laser Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application Notes
Additional reported applications (for the relevant formats) include: immunoprecipitation3, immunohistochemical staining of *-fixed frozen sections3, immunofluorescence microscopy5, 9 (Alexa Fluor® 488 conjugated N418 was used for IHC in frozen sections10), and spatial biology (IBEX)22,23.
Antigen Details
Structure Integrin α-chain, associates with integrin β2 (CD18), 150 kD
Distribution
Dendritic cells, NK cells, intestinal intraepithelial lymphocytes (IEL), some activated T cells
Function Cellular adhesion
Ligand/Receptor iC3b, fibrinogen
Cell Type Dendritic cells, Epithelial cells, NK cells, T cells, Tregs
Biology Area Cell Adhesion, Cell Biology, Costimulatory Molecules, Immunology, Innate Immunity, Neuroscience, Neuroscience Cell Markers
Molecular Family Adhesion Molecules, CD Molecules
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BioLegend 117308 PE anti-mouse CD11c
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