BioLegend 161103 PE/Fire™ 640

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BioLegend 161103 PE/Fire™ 640 anti-mouse CD11c Recombinant
产品简介：
产品品牌：BioLegend
产品货号：161103
产品名称：BioLegend 161103 PE/Fire™ 640 anti-mouse CD11c Recombinant
产品规格：25 µg

产品说明：
Clone  QA18A72 (See other available formats)
Regulatory Status  RUO
Other Names  αX integrin, integrin αX chain, CR4, p150, ITGAX
Isotype  Rat IgG1, κ

描述
CD11c是一种150kD的糖蛋白，也称为αX整合素、CR4和p150。CD11c与β2整合素（CD18）形成αXβ2异二聚体。它主要在树突状细胞、NK细胞、肠上皮内淋巴细胞亚群（IEL）和一些活化的T细胞上表达。αXβ2整合素通过结合其配体iC3b、纤维蛋白原和CD54在细胞-细胞接触中发挥重要作用。
CD11c is a 150 kD glycoprotein also known as αX integrin, CR4, and p150. CD11c forms a αXβ2 heterodimer with β2 integrin (CD18). It is primarily expressed on dendritic cells, NK cells, a subset of intestinal intraepithelial lymphocytes (IEL), and some activated T cells. The αXβ2 integrin plays an important role in cell-cell contact by binding its ligands: iC3b, fibrinogen, and CD54.

Product Details
Verified Reactivity   Mouse
Antibody Type   Recombinant
Host Species  Rat
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation
The antibody was purified by affinity chromatography and conjugated with PE/Fire™ 640 under optimal conditions.
Concentration  0.2 mg/mL
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application   FC - Quality tested

Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.06 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.

* PE/Fire™ 640 has a maximum excitation of 566 nm and a maximum emission of 639 nm.

Excitation Laser   Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)

Antigen Details
Structure   Integrin α-chain, associates with integrin β2 (CD18), 150 kD
Distribution
Dendritic cells, NK cells, intestinal intraepithelial lymphocytes (IEL), some activated T cells

Function   Cellular adhesion
Ligand/Receptor   iC3b, fibrinogen
Cell Type   Dendritic cells, Epithelial cells, NK cells, T cells, Tregs
Biology Area
Cell Adhesion,   Cell Biology, Costimulatory Molecules, Immunology, Innate Immunity, Neuroscience, Neuroscience Cell Markers.
Molecular Family Adhesion Molecules, CD Molecules

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