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99
- 英文名：
PE anti-mouse CD210 (IL-10 R)
- 供应商：
北京云肽生物科技有限公司
BioLegend 112705 PE anti-mouse CD210 (IL-10 R)
北京云肽生物科技有限公司作为BioLegend的特约经销商，为广大客户提供原装正品，货期短，折扣好的服务准则。
美国BioLegend公司位于美国加州，致力于为生物医药研究的各个前沿领域提供高质量的抗体及其它相关试剂。BioLegend虽然成立的时间不长，但它聚集了一批来自PharMingen公司的专业人士，建立了一支具有雄厚技术背景的专业队伍。通过其自身的先天优势，以及与世界知名实验室和研究所的良好合作关系，以合理的价格为广大客户提供高质量的免疫学和细胞生物学产品。BioLegend公司以其专业技术力量为保证，提供各种质量卓越的产品，并不断地开发新产品，以满足飞速发展的生命科学研究的需要。
BioLegend 112705 PE anti-mouse CD210 (IL-10 R)
产品简介：
产品品牌：BioLegend
产品货号：112705
产品名称：BioLegend 112705 PE anti-mouse CD210 (IL-10 R)
产品规格：50 µg
产品说明：
Clone 1B1.3a (See other available formats)
Regulatory Status RUO
Other Names IL-10R, Interleukin-10 Receptor
Isotype Rat IgG1, κ
描述
CD210是一种90-110kD的IL-10受体。它是一种II类细胞因子受体，在胸腺细胞、T细胞、B细胞、NK细胞、单核细胞和巨噬细胞上表达。CD210的配体结合诱导Jak1和Tyk，导致STAT1和STAT3活化。IL-10受体刺激导致细胞因子产生的抑制以及B细胞增殖和分化的共刺激。该受体唯一已知的配体是IL-10。
CD210 is a 90-110 kD IL-10 receptor. It is a class II cytokine receptor expressed on thymocytes, T cells, B cells, NK cells, monocytes and macrophages. Ligand binding of CD210 induces Jak1 and Tyk, resulting in STAT1 and STAT3 activation. IL-10 receptor stimulation results in the inhibition of cytokine production and the costimulation of B cell proliferation and differentiation. The only known ligand for this receptor is IL-10.
Product Details
Isotype Control PE Rat IgG1, κ Isotype Ctrl
Verified Reactivity Mouse
Antibody Type Monoclonal
Host Species Rat
Immunogen SolublemIL-10R-FLAG-His
Formulation Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.
Concentration 0.2 mg/ml
Storage & Handling The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application FC - Quality tested
Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
Excitation Laser Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application Notes
Additional reported applications (for the relevant formats) include: in vitro and in vivo blocking of ligand binding1-5. For most successful immunofluorescent staining results, it may be important to maximize signal over background by using a relatively bright fluorochrome-antibody conjugate (Cat. No. 112706) or by using a high sensitivity, three-layer staining technique (e.g., including a biotinylated antibody (Cat. No. 112704) or biotinylated anti-rat IgG (Cat. No. 405402) second step, followed by SAv-PE (Cat. No. 405204)). The LEAF™ purified antibody (Endotoxin < 0.1 EU/µg, Azide-Free, 0.2 µm filtered) is recommended for functional assays. For in vivo studies or highly sensitive assays, we recommend Ultra-LEAF™ purified antibody (Cat. No. 112710) with a lower endotoxin limit than standard LEAF™ purified antibodies (Endotoxin < 0.01 EU/µg).
Antigen Details
Structure Class II cytokine receptor family, 90-110 kD
Distribution
Thymocytes, T and B cells, NK cells, monocytes, macrophages
Function Inhibits cytokine production, costimulates B cell proliferation and differentiation
Ligand/Receptor IL-10
Cell Type B cells, Macrophages, Monocytes, NK cells, T cells, Thymocytes
Biology Area Immunology
Molecular Family CD Molecules, Cytokine/Chemokine Receptors
以下是BioLegend 品牌部分产品，如需其他产品请联系本公司销售。
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BioLegend 102059 Ultra-LEAF™ Purified anti-mouse CD25 PC61 25 mg
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BioLegend 102101 Purified anti-mouse CD28 37.51 50 ug
BioLegend 102102 Purified anti-mouse CD28 37.51 500 ug
BioLegend 102103 Biotin anti-mouse CD28 37.51 50 ug
BioLegend 102104 Biotin anti-mouse CD28 37.51 500 ug
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BioLegend 102106 PE anti-mouse CD28 37.51 200 ug
BioLegend 102109 APC anti-mouse CD28 37.51 25 ug
BioLegend 102110 APC anti-mouse CD28 37.51 100 ug
BioLegend 102114 PerCP/Cyanine5.5 anti-mouse CD28 37.51 100 ug
BioLegend 102115 Ultra-LEAF™ Purified anti-mouse CD28 37.51 100 ug
BioLegend 102122 Ultra-LEAF™ Purified anti-mouse CD28 37.51 25 mg
BioLegend 102125 PE/Cyanine7 anti-mouse CD28 37.51 25 ug
BioLegend 102126 PE/Cyanine7 anti-mouse CD28 37.51 100 ug
BioLegend 102127 Brilliant Violet 421™ anti-mouse CD28 37.51 50 ug
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文献和实验相关实验
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exhausted CD8+ T cells by IL-10 enhances anti-tumor immunity 的研究成果。该研究发现，IL-10 通过上调线粒体丙酮酸载体依赖的氧化磷酸化，从而介导 T 细胞代谢重编程，进而恢复终末耗竭 T 细胞的活力，并增强癌症免疫治疗的反应。 图片来源：Nature Immunology研究内容IL-10 直接扩增终末耗竭的 CD8 + 细胞作者首先制备了重组的人 IL-10 和 IgG1 Fc 的融合蛋白（IL-10–Fc），该蛋白可以与小鼠 IL-10 受体
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BioLegend 112705 PE anti-mouse CD210 (IL-10 R)
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