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- 库存：
99
- 英文名：
PE/Cyanine7 anti-mouse CD127 (IL-7Rα)
- 供应商：
北京云肽生物科技有限公司
BioLegend 135014 PE/Cyanine7 anti-mouse CD127 (IL-7Rα)
北京云肽生物科技有限公司作为BioLegend的特约经销商，为广大客户提供原装正品，货期短，折扣好的服务准则。
美国BioLegend公司位于美国加州，致力于为生物医药研究的各个前沿领域提供高质量的抗体及其它相关试剂。BioLegend虽然成立的时间不长，但它聚集了一批来自PharMingen公司的专业人士，建立了一支具有雄厚技术背景的专业队伍。通过其自身的先天优势，以及与世界知名实验室和研究所的良好合作关系，以合理的价格为广大客户提供高质量的免疫学和细胞生物学产品。BioLegend公司以其专业技术力量为保证，提供各种质量卓越的产品，并不断地开发新产品，以满足飞速发展的生命科学研究的需要。
BioLegend 135014 PE/Cyanine7 anti-mouse CD127 (IL-7Rα)
产品简介：
产品品牌：BioLegend
产品货号：135014
产品名称：BioLegend 135014 PE/Cyanine7 anti-mouse CD127 (IL-7Rα)
产品规格：100 µg
产品说明：
Clone A7R34 (See other available formats)
Regulatory Status RUO
Other Names IL-7 receptor α chain, IL-7Rα
Isotype Rat IgG2a, κ
描述
CD127是一种60-90 kD的I型跨膜糖蛋白，也称为IL-7受体α链或IL-7Rα。它与常见的γ链（γc或CD132）形成异二聚体，与IL-2、IL-4、IL-9、IL-13、IL-15和IL-21的受体共享。CD127在未成熟B细胞、胸腺细胞（CD4/CD8双阳性胸腺细胞除外）、外周T细胞和骨髓基质细胞上表达。CD127已被报道为用于识别记忆和效应T细胞的有用标记物。IL-7与其受体的连接对于刺激成熟和未成熟的T细胞以及未成熟的B细胞增殖和发育是重要的。
CD127 is a 60-90 kD type I transmembrane glycoprotein also known as IL-7 receptor α chain or IL-7Rα. It forms a heterodimer with the common γ chain (γc or CD132) which is shared with the receptors for IL-2, IL-4, IL-9, IL-13, IL-15, and IL-21. CD127 is expressed on immature B cells through early pre-B stage, thymocytes (except CD4/CD8 double positive thymocytes), peripheral T cells, and bone marrow stromal cells. CD127 has been reported to be an useful marker for identifying memory and effector T cells. The ligation of IL-7 with its receptor is important for stimulation of mature and immature T cells as well as immature B cells proliferation and development.
Product Details
Isotype Control PE/Cyanine7 Rat IgG2a, κ Isotype Ctrl
Verified Reactivity Mouse
Antibody Type Monoclonal
Host Species Rat
Immunogen IL-7Ra-IgG1 fusion protein
Formulation Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography, and conjugated with PE/Cyanine7 under optimal conditions.
Concentration 0.2 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application FC - Quality tested
Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
Excitation Laser Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application Notes
A7R34 is able to block clone SB/199 binding to IL-7R.
Additional Product Notes
BioLegend is in the process of converting the name PE/Cy7 to PE/Cyanine7. The dye molecule remains the same, so you should expect the same quality and performance from our PE/Cyanine7 products. Please contact Technical Service if you have any questions.
Antigen Details
Structure Type I transmembrane glycoprotein, associate with CD132, 60-90 kD
Distribution
Immature B cells through early pre-B stage, thymocytes (except CD4/CD8 double positive thymocytes), peripheral T cells, bone marrow stromal cells
Function T cell and immature B cell proliferation and development
Ligand/Receptor IL-7
Cell Type B cells, T cells, Thymocytes
Biology Area Immunology
Molecular Family
CD Molecules, Cytokine/Chemokine Receptors
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BioLegend 135014 PE/Cyanine7 anti-mouse CD127 (IL-7Rα)
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