产品说明: Clone A7R34 (See other available formats) Regulatory Status RUO Other Names IL-7 receptor α chain, IL-7Rα Isotype Rat IgG2a, κ
描述 CD127是一种60-90 kD的I型跨膜糖蛋白,也称为IL-7受体α链或IL-7Rα。它与常见的γ链(γc或CD132)形成异二聚体,与IL-2、IL-4、IL-9、IL-13、IL-15和IL-21的受体共享。CD127在未成熟B细胞、胸腺细胞(CD4/CD8双阳性胸腺细胞除外)、外周T细胞和骨髓基质细胞上表达。CD127已被报道为用于识别记忆和效应T细胞的有用标记物。IL-7与其受体的连接对于刺激成熟和未成熟的T细胞以及未成熟的B细胞增殖和发育是重要的。 CD127 is a 60-90 kD type I transmembrane glycoprotein also known as IL-7 receptor α chain or IL-7Rα. It forms a heterodimer with the common γ chain (γc or CD132) which is shared with the receptors for IL-2, IL-4, IL-9, IL-13, IL-15, and IL-21. CD127 is expressed on immature B cells through early pre-B stage, thymocytes (except CD4/CD8 double positive thymocytes), peripheral T cells, and bone marrow stromal cells. CD127 has been reported to be an useful marker for identifying memory and effector T cells. The ligation of IL-7 with its receptor is important for stimulation of mature and immature T cells as well as immature B cells proliferation and development.
Product Details Isotype Control PE/Cyanine7 Rat IgG2a, κ Isotype Ctrl Verified Reactivity Mouse Antibody Type Monoclonal Host Species Rat Immunogen IL-7Ra-IgG1 fusion protein Formulation Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide. Preparation The antibody was purified by affinity chromatography, and conjugated with PE/Cyanine7 under optimal conditions.
Concentration 0.2 mg/ml Storage & Handling The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze. Application FC - Quality tested
Recommended Usage Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application. Excitation Laser Blue Laser (488 nm) Green Laser (532 nm)/Yellow-Green Laser (561 nm) Application Notes A7R34 is able to block clone SB/199 binding to IL-7R.
Additional Product Notes BioLegend is in the process of converting the name PE/Cy7 to PE/Cyanine7. The dye molecule remains the same, so you should expect the same quality and performance from our PE/Cyanine7 products. Please contact Technical Service if you have any questions.
Antigen Details Structure Type I transmembrane glycoprotein, associate with CD132, 60-90 kD Distribution Immature B cells through early pre-B stage, thymocytes (except CD4/CD8 double positive thymocytes), peripheral T cells, bone marrow stromal cells
Function T cell and immature B cell proliferation and development Ligand/Receptor IL-7 Cell Type B cells, T cells, Thymocytes Biology Area Immunology Molecular Family CD Molecules, Cytokine/Chemokine Receptors
以下是BioLegend 品牌部分产品,如需其他产品请联系本公司销售。 BioLegend 120120 Brilliant Violet 421™ anti-mouse CD197 (CCR7) 4B12 500 uL BioLegend 120122 PE/Dazzle™ 594 anti-mouse CD197 (CCR7) 4B12 100 ug BioLegend 120123 PE/Cyanine7 anti-mouse CD197 (CCR7) 4B12 25 ug BioLegend 120124 PE/Cyanine7 anti-mouse CD197 (CCR7) 4B12 100 ug BioLegend 120127 Brilliant Violet 785™ anti-mouse CD197 (CCR7) 4B12 50 ug BioLegend 120205 FITC anti-mouse CD357 (GITR) YGITR 765 50 ug BioLegend 120401 Purified anti-mouse CD105 MJ7/18 50 ug BioLegend 120402 Purified anti-mouse CD105 MJ7/18 500 ug BioLegend 120403 Biotin anti-mouse CD105 MJ7/18 50 ug BioLegend 120406 Alexa Fluor® 488 anti-mouse CD105 MJ7/18 100 ug BioLegend 120407 PE anti-mouse CD105 MJ7/18 25 ug BioLegend 120408 PE anti-mouse CD105 MJ7/18 100 ug BioLegend 120411 Pacific Blue™ anti-mouse CD105 MJ7/18 25 ug BioLegend 120412 Pacific Blue™ anti-mouse CD105 MJ7/18 100 ug BioLegend 120413 APC anti-mouse CD105 MJ7/18 25 ug BioLegend 120414 APC anti-mouse CD105 MJ7/18 100 ug BioLegend 120415 PerCP/Cyanine5.5 anti-mouse CD105 MJ7/18 25 ug BioLegend 120431 APC/Cyanine7 anti-mouse CD105 MJ7/18 25 ug BioLegend 120501 Purified anti-mouse Panendothelial Cell Antigen MECA-32 50 ug BioLegend 120605 PE anti-mouse LPAM-1 (Integrin α4β7) DATK32 50 ug BioLegend 120607 APC anti-mouse LPAM-1 (Integrin α4β7) DATK32 25 ug BioLegend 120608 APC anti-mouse LPAM-1 (Integrin α4β7) DATK32 100 ug