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MedChemExpress LLC
- CAS号:
2877011-84-0
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询盘
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Aurora Kinases-IN-4
CAS No. : 2877011-84-0
MCE 国际站:Aurora Kinases-IN-4
产品活性:Aurora Kinases-IN-4 (Compound 11c) 是一种共价 ATP 竞争性 aurora kinase A 抑制剂 (IC50: 1.7 nM)。Aurora Kinases-IN-4 抑制 SJSA-1、MDA-MB-231、A54、HeLa 细胞的细胞增殖,IC50s 为 4.27、1.54、3.08、6.99 μM。Aurora Kinases-IN-4 可用于三阴性乳腺癌 (TNBC) 的研究。
研究领域:Cell Cycle/DNA Damage | Epigenetics
作用靶点:Aurora Kinase
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文献和实验A method for analyzing the ubiquitination and degradation of aurora-A
many other regulatory proteins. Aurora kinases are involved in mitotic spindle formation as well as in cytokinesis. The abundance and activity of the kinase is precisely regulated during the cell cycle. To understand how proteolysis regulates transitions
Studying the Roles of Aurora-C Kinase During Meiosis in Mouse Oocytes
We previously isolated Aurora-C (Aurkc/Aie1 ) in a screen for kinases expressed in mouse sperm and eggs. Aurora-C kinase was reported to be a chromosomal passenger protein that plays critical roles in chromosome alignment
The Ipl1/Aurora Kinase Family: Methods of Inhibition and Functional Analysis in Mammalian Cells
The Ipl1/Aurora family of protein kinases are required for accurate chromosome segregation. Because members of this family are often overexpressed in human tumors, they have recently received much attention, both from the academic community
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