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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
2840558-83-8
- 规格：
5 mg/10 mg
| 规格： | 5 mg | 产品价格： | ￥1900.0 |
|---|---|---|---|
| 规格： | 10 mg | 产品价格： | ￥3000.0 |
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Aurora Kinases-IN-3
CAS No. : 2840558-83-8
MCE 国际站：Aurora Kinases-IN-3
产品活性：Aurora Kinases-IN-3 (Compound 15a) 是一种具有口服活性的 AURKB 抑制剂，通过破坏 AURKB 的有丝分裂定位，而不是抑制其在 Ser10 位点 H3 的磷酸化，从而诱导 AURKB 抑制活性。
研究领域：Cell Cycle/DNA Damage | Epigenetics
作用靶点：Aurora Kinase | Polo-like Kinase (PLK)
In Vitro: Aurora Kinases-IN-3 (Compound 15a) (40 nM; 6 h) disrupts localization of AURKB, MKLP1, and PLK at the spindle midzone to prevent spindle midzone microtubule assembly in RPE-MYCBCL2 cells. Aurora Kinases-IN-3 disrupts the localization of AURKB as early as anaphase, producing downstream consequences that blocked cytokinesis.
Aurora Kinases-IN-3 (1-10 μM; 3 days) shows wide spectrum of growth suppression in human cancer cell lines.
In Vivo: Aurora Kinases-IN-3 (Compound 15a) (50 mg/kg; oral; twice a day for 7 days) suppresses the growth of lung tumors in mice.
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文献和实验A method for analyzing the ubiquitination and degradation of aurora-A
many other regulatory proteins. Aurora kinases are involved in mitotic spindle formation as well as in cytokinesis. The abundance and activity of the kinase is precisely regulated during the cell cycle. To understand how proteolysis regulates transitions
Studying the Roles of Aurora-C Kinase During Meiosis in Mouse Oocytes
We previously isolated Aurora-C (Aurkc/Aie1 ) in a screen for kinases expressed in mouse sperm and eggs. Aurora-C kinase was reported to be a chromosomal passenger protein that plays critical roles in chromosome alignment
The Ipl1/Aurora Kinase Family: Methods of Inhibition and Functional Analysis in Mammalian Cells
The Ipl1/Aurora family of protein kinases are required for accurate chromosome segregation. Because members of this family are often overexpressed in human tumors, they have recently received much attention, both from the academic community
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