Peprotech(Biogems) 1066656-100

Peprotech(Biogems) 1066656-100g Valproic Acid

2014年PeproTech公司推出自己的流式细胞术产品品牌，即BioGems。BioGems意为生物钻石，其产品涵盖多种荧光标记的流式抗体、具有生物活性的功能性抗体，以及流式细胞术辅助试剂，如溶血剂和破膜剂等。BioGems产品全部在美国生产，相信其优异的品质和低于其它国际流式厂商的价位将能为广大用户提供更好的选择。

我们北京云肽生物科技有限公司作为Peprotech(Biogems)公司的特约经销商为客户提供，正规进口，保证原装正品，货期稳定，折扣好的服务标准。

Peprotech(Biogems) 1066656-100g Valproic Acid，产品简介：
产品品牌：Peprotech(Biogems)
产品货号：1066656-100g
产品名称：Valproic Acid
产品规格：100g


产品说明：
丙戊酸（VPA）是一种组蛋白去乙酰化酶（HDAC）抑制剂，具有抗炎，神经保护和抗惊厥特性。它还抑制γ-氨基丁酸（GABA）代谢中的酶，导致GABA水平升高，并消耗细胞肌醇合成。据报道，VPA可促进造血祖细胞的自我更新和分化，并与其他小分子和生长因子结合，可用于产生诱导多能干细胞。

Valproic Acid (VPA) is a histone deacetylase (HDAC) inhibitor with anti-inflammatory, neuroprotective and anticonvulsant properties. It also inhibits the enzymes in gamma-Aminobutyric acid (GABA) metabolism leading to increased levels of GABA and also, to deplete cellular inositol synthesis. VPA is reported to promote the self-renewal and differentiation of hematopoietic progenitor cells and be useful in generating induced pluripotent stem cells, in combination with other small molecules and growth factors.

产品信息：
应用: FA
同义词: 2-Propylpentanoic Acid, Convulsofin, Depakene, Depakine, Divalproex, Ergenyl
配方: Crystalline solid
化学名称: sodium;2-propylpentanoate
分子式: C₈H₁₅O₂Na
分子量: 166.2
CAS号：1069-66-5
纯度：≥95%
储存条件：产品应保持在-20°C。
参考：
Phiel, C. J., Zhang, F., Huang, E. Y., Guenther, M. G., Lazar, M. A., & Klein, P. S. (2001). Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen. Journal of Biological Chemistry,276(39), 36734-36741.

Göttlicher, M., Minucci, S., Zhu, P., Krämer, O. H., Schimpf, A., Giavara, S., ... & Heinzel, T. (2001). Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells. The EMBO journal, 20(24), 6969-6978.

Bug, G., Gül, H., Schwarz, K., Pfeifer, H., Kampfmann, M., Zheng, X., ... & Ruthardt, M. (2005). Valproic acid stimulates proliferation and self-renewal of hematopoietic stem cells. Cancer Research, 65(7), 2537-2541.

Huangfu, D., Maehr, R., Guo, W., Eijkelenboom, A., Snitow, M., Chen, A. E., & Melton, D. A. (2008). Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds. Nature biotechnology, 26(7), 795-797.

产品订购信息：

品牌	货号	产品名称	规格
Peprotech(Biogems)	1066656-100g	Valproic Acid	100g
Peprotech(Biogems)	1066656-25g	Valproic Acid	25g