EasyGo!™ 小鼠TNF-α Mouse TNF-α O

TNF 分子靶点信息概述

• 分子名：TNF, tumor necrosis factor
• 基因家族：Tumor necrosis factor superfamily
• 别名：TNFSF2; DIF; TNF-alpha
• 曾用名：TNFA
• 全称：TNF superfamily, member 2; tumor necrosis factor (TNF superfamily, member 2)

TNF 分子靶点综述

肿瘤坏死因子α (TNF-α)，也称为恶病质素和 TNFSF1A，是一种脂肪因子，参与全身的炎症，同时也是刺激急性期反应的细胞因子之一。它主要由活化的巨噬细胞产生，也可由其它类型的细胞分泌，如 CD4+淋巴细胞、NK 细胞、中性粒细胞、肥大细胞、嗜酸性粒细胞和神经元等。它在免疫应答中具有多种调节功能，还可作为潜在的热原。TNF-α对刺激物 (感染因子或组织受损) 产生应答后，在全身循环，激活中性粒细胞，改变血管内皮细胞的特性，调控其它组织的代谢活性，以及通过诱导局部凝血作用展现肿瘤杀伤活性。TNF-α在关节组织和其它组织发生炎症的发病机制具有重要作用。最近，越来越多的信息表明 TNF-α也参与了 AIDS 的发病机制。TNF-α 的测定对于移植研究也非常有用。

小鼠 Mouse Tnf 分子靶点信息

• 分子名：Tnf, tumor necrosis factor
• 别称：
  • DIF
  • TNF alpha
  • TNF-alpha
  • Tnfa
  • TNFalpha
  • Tnfsf1a
  • tumor necrosis factor-alpha
  • tumor necrosis factor, alpha
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小鼠 Mouse Tnf 靶点分子功能（预测）

Enables cytokine activity; protease binding activity; and tumor necrosis factor receptor binding activity. Involved in several processes, including endothelial cell apoptotic process; positive regulation of cell communication; and positive regulation of macromolecule metabolic process. Acts upstream of or within several processes, including apoptotic signaling pathway; positive regulation of intracellular signal transduction; and regulation of gene expression. Located in several cellular components, including external side of plasma membrane; phagocytic cup; and recycling endosome. Is expressed in several structures, including alimentary system; brain; integumental system; lung; and reproductive system. Used to study several diseases, including autoimmune disease (multiple); congestive heart failure; heart valve disease (multiple); idiopathic pulmonary fibrosis; and spondyloarthropathy. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); eye disease (multiple); lung disease (multiple); and skin disease (multiple). Orthologous to human TNF (tumor necrosis factor).