Viral polymerase-IN-1,2367587-

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Viral polymerase-IN-1 hydrochloride

CAS No. : 2367587-02-6

MCE 国际站：Viral polymerase-IN-1 hydrochloride

产品活性：Viral polymerase-IN-1 hydrochloride 是一种 Gemcitabine (HY-17026) 衍生物，有效抑制甲型和乙型流感病毒 (influenza) 感染，IC₉₀ 值为 11.4-15.9 μM。Viral polymerase-IN-1 hydrochloride 对 SARS-CoV-2 感染具有活性。Viral polymerase-IN-1 hydrochloride 通过影响细胞中的病毒 RNA 复制/转录来抑制流感病毒感染。

研究领域：Anti-infection

作用靶点：Influenza Virus  |  SARS-CoV

In Vitro: Viral polymerase-IN-1 hydrochloride (compound 2h; 0.1, 1, 10 μM; overnight) reduces viral NP protein expression and viral RNA copies in a dose-dependent manner.
Viral polymerase-IN-1 hydrochloride (11, 33, 100 μM, 72 h) potently inhibits viral polymerase activity in a dose-dependent manner on the polymerase activity of influenza A virus PR8 in human cells, HeLa.
Viral polymerase-IN-1 hydrochloride efficiently inhibits SARS-CoV-2 infection with an EC₅₀ value of 0.46 μM and a CC₅₀ value above 100 μM, resulting in an SI value of >217.4 in Calu-3 cells.

In Vivo: Viral polymerase-IN-1 hydrochloride (compound 2h; 5 mg/kg; IP; once daily for 5 days, beginning 4 h prior to virus infection) not only reduces viral RNA level in the lungs but also alleviates infection-mediated pulmonary infiltrates in mice.

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