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2570797-85-0
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电询
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HSGN-94
CAS No. : 2570797-85-0
MCE 国际站：HSGN-94
产品活性：HSGN-94 是一种有效的抗菌剂，可抑制脂磷酸 (LTA) 生物合成。HSGN-94 抑制耐药革兰氏阳性菌，MIC 值为 0.25-2 μg/mL。HSGN-94 抑制 MRSA 和耐 Vancomycin (HY-B0671) 的 Enterococci 的生物膜形成。HSGN-94 还抑制促炎细胞因子，在 MRSA 小鼠伤口感染模型中表现出体内功效。
研究领域：Anti-infection
作用靶点：Bacterial
In Vitro: HSGN-94 (50 μM; 30 min) directly binds to CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase (PgsA).
HSGN-94 (0.25 μg/mL; 2 h) downregulates the expression level of PgsA, an essential protein for phospholipid synthesis in the bacteria S. aureus.
HSGN-94 (16, 32, 64, and 128 μg/mL; 2 h) is not toxic to HaCat cells at concentrations up to 64 μg/mL.
In Vivo: HSGN-94 (2%; external use; twice daily for 5 days) decreases MRSA USA300 in infected wounds of mice and results resolution of inflammation in infection model.
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文献和实验01 靶点：FAM134B/RETREG1 应用：阿尔茨海默病（AD）治疗的潜在靶点 来源：FAM134B-mediated ER-phagy degrades APP and suppresses Alzheimer’s disease pathology.EMBO J, 2026 Jul 图源：10.1038/s44318-026-00818-9[1] 武汉大学医学研究院崔逸仙教授团队近期在The EMBO Journal发表了一篇研究，揭示了内质网自噬受体
Lacrimal Experimental Protocol (4/4/94)
Lacrimal Experimental Protocol (4/4/94) Day Before: 1. Prepare (6) 50 ml conicals each containing 50 ml of DMEM (high glucose) and gentamycin (50 µg/ml); place in incubator (90% O2, 10% CO2). 2. Thaw FBS (place at 4°C).
Molecular Analysis of p94 and Its Application to Diagnosis of Limb Girdle Muscular Dystrophy Type 2A
p94 (also called calpain 3, nCL-1, or CAPN3) is a calpain large subunit homologue, which is predominantly expressed in skeletal muscle (1 –4 ). The mRNA level of p94 in skeletal muscle is at least 10 times higher
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