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货期：电询
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MedChemExpress LLC
- CAS号：
2570797-85-0
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电询
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HSGN-94
CAS No. : 2570797-85-0
MCE 国际站：HSGN-94
产品活性：HSGN-94 是一种有效的抗菌剂，可抑制脂磷酸 (LTA) 生物合成。HSGN-94 抑制耐药革兰氏阳性菌，MIC 值为 0.25-2 μg/mL。HSGN-94 抑制 MRSA 和耐 Vancomycin (HY-B0671) 的 Enterococci 的生物膜形成。HSGN-94 还抑制促炎细胞因子，在 MRSA 小鼠伤口感染模型中表现出体内功效。
研究领域：Anti-infection
作用靶点：Bacterial
In Vitro: HSGN-94 (50 μM; 30 min) directly binds to CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase (PgsA).
HSGN-94 (0.25 μg/mL; 2 h) downregulates the expression level of PgsA, an essential protein for phospholipid synthesis in the bacteria S. aureus.
HSGN-94 (16, 32, 64, and 128 μg/mL; 2 h) is not toxic to HaCat cells at concentrations up to 64 μg/mL.
In Vivo: HSGN-94 (2%; external use; twice daily for 5 days) decreases MRSA USA300 in infected wounds of mice and results resolution of inflammation in infection model.
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文献和实验Lacrimal Experimental Protocol (4/4/94)
Lacrimal Experimental Protocol (4/4/94) Day Before: 1. Prepare (6) 50 ml conicals each containing 50 ml of DMEM (high glucose) and gentamycin (50 µg/ml); place in incubator (90% O2, 10% CO2). 2. Thaw FBS (place at 4°C).
Molecular Analysis of p94 and Its Application to Diagnosis of Limb Girdle Muscular Dystrophy Type 2A
p94 (also called calpain 3, nCL-1, or CAPN3) is a calpain large subunit homologue, which is predominantly expressed in skeletal muscle (1 –4 ). The mRNA level of p94 in skeletal muscle is at least 10 times higher
，1000，2000 bp 片段，以 pBS 质粒为模板扩增 1500 bp 片段。 模板：pUC19 质粒 30 ng/50 μL or pBS 质粒 30 ng/50 μL PCR 扩增程序： 循环数 Step 温度 时间 1 1 94 ℃ 2 min 35 1 94 ℃ 45 sec 2 55 ℃ 45 sec 3 72 ℃ 2 min 1 1 72 ℃ 5 min 2．质粒菌液直接扩增： 以 pUC19 菌液为模板扩增 100，250，500，750，1000
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