使用方法(数据来自于公开发表的文献,仅供参考)(一)细胞实验(体外实验) Echinacoside可以剂量依赖性地降低MDA-MB-231和MDA-MB-468细胞的增殖和迁移能力,并且下调细胞中phosho-LRP6、总LRP6、phosho-Dvl2、活性β-catenin和总β-catenin蛋白的表达水平。[1] Echinacoside保护TrkA或TrkB过度表达的神经元细胞和非神经元细胞免受鱼藤酮损伤。[2] Echinacoside (0.01~10 nM)促进MC3T3-E1细胞增殖、ALP活性、COL I含量、OCN水平和成骨细胞矿化。[3] (二)动物实验(体内实验) 在骨质酥松大鼠模型中,口服Echinacoside (30-270 mg/kg),缓解了骨质酥松大鼠体重,导致了血清羟脯氨酸 (HOP)水平的增加和子宫湿重和BMD的降低。[4] 在急性肝损伤小鼠模型中,腹腔注射60 mg/kg Echinacoside提高了小鼠的存活率,并减轻了急性肝毒性。[5] 参考文献[1]. Tang C, et al. Echinacoside inhibits breast cancer cells by suppressing the Wnt/β-catenin signaling pathway. Biochem Biophys Res Commun. 2020 May 21;526(1):170-175. [2]. Zhu M, et al. Transient exposure to echinacoside is sufficient to activate Trk signaling and protect neuronal cells from rotenone. J Neurochem. 2013 Feb;124(4):571-80. [3]. Li F, et al. Echinacoside promotes bone regeneration by increasing OPG/RANKL ratio in MC3T3-E1 cells. Fitoterapia. 2012 Dec;83(8):1443-50. [4].Li F, et al. Antiosteoporotic activity of echinacoside in ovariectomized rats. Phytomedicine. 2013 Apr 15;20(6):549-57. [5]. Li X, et al. Echinacoside ameliorates D-galactosamine plus lipopolysaccharide-induced acute liver injury in mice via inhibition of apoptosis and inflammation. Scand J Gastroenterol. 2014 Aug;49(8):993-1000.
[1]. Tang C, et al. Echinacoside inhibits breast cancer cells by suppressing the Wnt/β-catenin signaling pathway. Biochem Biophys Res Commun. 2020 May 21;526(1):170-175.
[2]. Zhu M, et al. Transient exposure to echinacoside is sufficient to activate Trk signaling and protect neuronal cells from rotenone. J Neurochem. 2013 Feb;124(4):571-80.
[3]. Li F, et al. Echinacoside promotes bone regeneration by increasing OPG/RANKL ratio in MC3T3-E1 cells. Fitoterapia. 2012 Dec;83(8):1443-50.
[4]. Li F, et al. Antiosteoporotic activity of echinacoside in ovariectomized rats. Phytomedicine. 2013 Apr 15;20(6):549-57.
[5]. Li X, et al. Echinacoside ameliorates D-galactosamine plus lipopolysaccharide-induced acute liver injury in mice via inhibition of apoptosis and inflammation. Scand J Gastroenterol. 2014 Aug;49(8):993-1000.