cRIPGBM,2361988-77-2

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cRIPGBM chloride

CAS No. : 2361988-77-2

MCE 国际站：cRIPGBM chloride

产品活性：cRIPGBM chloride 是一种口服有效的促凋亡衍生物，cRIPGBM 可从多形性胶质母细胞瘤 (GBM) 癌症干细胞 (CSC) 中产生。cRIPGBM chloride 靶向受体相互作用蛋白激酶 2 (RIPK2) 以诱导半胱天冬酶 caspase 1 依赖性细胞凋亡。cRIPGBM chloride 抑制 RIPK2/TAK1 (促存活复合物) 的形成，并增加 RIPK2/caspase 1 (促凋亡复合物) 的形成。cRIPGBM chloride 在动物模型中发挥了强力的体内抗肿瘤活性。

研究领域：Apoptosis

作用靶点：RIP kinase  |  Caspase  |  Apoptosis

In Vitro: cRIPGBM chloride (0.25 μM; 0-24 h) time-dependently activates caspase 1, caspase 9, and caspase 7, as well as PARP cleavage, in CBM-1 GBM CSCs.
cRIPGBM chloride (0.125 μM, 0.25 μM; 24 h) induces cell apoptosis mediated by caspase 1 in CBM-1 GBM CSCs.

In Vivo: cRIPGBM chloride (50 mg/kg; p.o.; twice daily for 5 weeks) inhibits tumor growth in patient-derived GBM CSC intracranial xenograft mouse models.

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