Fasitibant,869939-83-3

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Fasitibant free base

CAS No. : 869939-83-3

MCE 国际站：Fasitibant free base

产品活性：Fasitibant (free base) 是一种强效、选择性、高亲和力、长效的非肽性缓激肽 B₂ 受体 (BK₂ receptor) 拮抗剂。Fasitibant (free base) 具有促炎作用，可用于骨关节炎和类风湿关节炎的研究。

研究领域：GPCR/G Protein

作用靶点：Bradykinin Receptor

In Vitro: Fasitibant (free base) (1 µM; 30 min) reduces BK induced PGE₂ formation and COX-2 gene expression in synovial cells.

In Vivo: Fasitibant (free base) (100 µg; knee injection; single dose) significantly reduces the release of IL-1b, IL-6, GRO/PINC-1 synovial cytokines, the formation of PGE metabolites, the activity of myeloperoxidase (MPO) induced by Carrageenan (HY-125474) in rats, and the effect was more significant when combined with Dexamethasone (HY-14648).

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