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文献和实验强迫游泳实验(Forced Swimming Test, FST)系统
强迫游泳实验(Forced Swimming Test, FST)系统主要用于抗抑郁、镇静以及止痛类药物的研究。该系统适用于大鼠、小鼠或其他实验室动物,通过将实验动物置于一个局限的环境中(如水中),动物在该环境中拼命挣扎试图逃跑又无法逃脱,从而提供了一个无可回避的压迫环境,一段时间的实验后,动物即表现出典型的“不动状态”,反映了一种被称之为“行为绝望状态”,记录处于该环境的动物产生绝望的不动状态过程中的一系列参数。该系统使用摄像头对实验过程录像并用相应软件
Generation of Antibody Molecules Through Antibody Engineering
been overcome to a large extent using genetic-engineering techniques to produce chimeric mouse/human and completely human antibodies. Such an approach is particularly suitable because of the domain structure of the antibody molecule ( 2 ), where functional
The importance of antibody molecules was first recognized in the 1890s, when it was shown that immunity to tetanus and diphtheria was caused by antibodies against the bacterial exotoxins (1 ). Around the same time, it was shown that antisera
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