重组人IgG1 Fc蛋白

重组人IgG1 Fc蛋白相关信息：

产品分类
重组蛋白
英文名称
Recombinant human IgG1 Fc protein, (HEK293)
中文名称
重组人IgG1 Fc蛋白
英文别名
Immunoglobulin heavy constant gamma 1, IGHG1
蛋白细胞定位
分子量
25.8
浓度
>1mg/ml
储存液
保存条件
Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles.

重组人IgG1 Fc蛋白

背景资料：As a monomeric immunoglobulin that is predominately involved in the secondary antibody response and the only isotype that can pass through the human placenta, Immunoglobulin G (IgG) is synthesized and secreted by plasma B cells, and constitutes 75% of serum immunoglobulins in humans. IgG antibodies protect the body against the pathogens by agglutination and immobilization, complement activation, toxin neutralization, as well as antibody-dependent cell-mediated cytotoxicity (ADCC). IgG tetramer contains two heavy chains (5 kDa ) and two light chains (25 kDa) linked by disulfide bonds, that is the two identical halves form the Y-like shape. IgG is digested by pepsin proteolysis into Fab fragment (antigen-binding fragment) and Fc fragment ("crystallizable" fragment). IgG1 is most abundant in serum among the four IgG subclasses (IgG1, 2, 3 and 4) and binds to Fc receptors (FcγR ) on phagocytic cells with high affinity. Fc fragment is demonstrated to mediate phagocytosis, trigger inflammation, and target Ig to particular tissues. Protein G or Protein A on the surface of certain Staphylococcal and Streptococcal strains specifically binds with the Fc region of IgGs, and has numerous applications in biotechnology as a reagent for affinity purification. Recombinant IgG Fc Region is suggested to represent a potential anti-inflammatory drug for treatment of human autoimmune diseases.

重组人IgG1 Fc蛋白应用：仅供研究使用，不用于临床诊断！




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