Coelonin,82344-82-9

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Coelonin

CAS No. : 82344-82-9

MCE 国际站：Coelonin

产品活性：Coelonin 是一种具有抗炎活性的二氢菲。Coelonin 可抑制 LPS 诱导的 PTEN 磷酸化。Coelonin 通过负向调节 PI3K/AKT 通路抑制 NF-κB 激活和 p27^Kip1 降解。Coelonin 可抑制 IκBα 的磷酸化和降解，增加 IκBα 蛋白的表达。

研究领域：PI3K/Akt/mTOR  |  NF-κB  |  Immunology/Inflammation  |  Apoptosis

作用靶点：PTEN  |  Akt  |  NF-κB  |  Interleukin Related  |  TNF Receptor

In Vitro: Coelonin (2.5 μg/mL) significantly reduces both NF-κB p65 and p105/50 phosphorylation levels.
Coelonin (0-5 μg/mL, 1.5 h) dose dependently reduces the increase of the phosphorylation of PTEN, AKT and IκBa induced by LPS.
Coelonin (10 and 20 μg/ml) mitigates particulate matter 2.5 (PM2.5)-induced inflammation by reducing the generation of inflammatory factors, including interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α).
The inhibition of IL-1β, IL-6 and TNF-α expression by Coelonin is independent of PTEN, whereas the inhibition of p27^Kip1 degradation results in cell-cycle arrest in the G1 phase, which is dependent on PTEN.

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