Eckol,88798-74-7

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Eckol

CAS No. : 88798-74-7

MCE 国际站：Eckol

产品活性：Eckol是一种有效的 hMAO-A (混合性) 和 hMAO-B (非竞争性) 抑制剂，IC₅₀ 分别为 7.20 和 83.44 μM。Eckol 对玉米有刺激作用，可作为植物生物刺激素使用。Eckol 还显示抗过敏和抗病毒 (antiviral) 作用。

研究领域：Neuronal Signaling  |  Anti-infection

作用靶点：Monoamine Oxidase  |  Influenza Virus

In Vitro: Pretreatment with Eckol (25-100 μg/mL; 2 h) significantly reduces β-hexosaminidase release in IgE/BSA-stimulated BMCMC in a dose-dependent manner.
Eckol (25-100 μg/mL; 1 h) inhibits the production of Th2-type cytokines, such as IL-4, IL-5, and IL-13 as well as proinflammatory cytokines, such as IL-6.
Eckol (25-100 μg/mL) attenuates cytokine mRNA levels such as IL-1β, IL-4, IL-5, IL-6, IL-13, IFN-γ, and TNF-α in IgE/BSA-stimulated BMCMC.
Eckol (25-100 μg/mL; 1 h) inhibits NF-κB activation in IgE/BSA-stimulated BMCMC.
Eckol showes a moderate IC₅₀ value (89.5 µM) against the influenza A/Bervig-Mission/1/18 (H1N1) virus.

In Vivo: Foliar application of Eckol (1 μM) significantly enhanced shoot and root length, shoot and root fresh and dry weight, leaf area and leaf number.
Eckol (50 or 100 μg/mouse; intradermal; once) reduces allergic inflammatory responses in the passive cutaneous anaphylaxis (PCA)-induced mice.

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