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Antiproliferative agent-18
CAS No. : 2882206-14-4
MCE 国际站：Antiproliferative agent-18
产品活性：Antiproliferative agent-18 (Compound 5k) 是一种抗增殖剂，还具有中度抗细菌 (anti-bacterial) 和抗真菌 (anti-fungi) 活性。
研究领域：Anti-infection
作用靶点：Fungal
In Vitro: Antiproliferative agent-18 (Compound 5k) (200 µg/ /8 mm disc; 24 h for bacteria, 48 h for fungi) displays moderate antibacterial activity (growth inhibition zones 14–17 mm) and is moderately active against the yeast-like pathogenic fungus Candida albicans (growth inhibition zone 17 mm).
Antiproliferative agent-18 (0.1-100 μM; 48 h) shows anti-proliferative activity against human prostate cancer (PC-3), colorectal carcinoma (HCT-116), hepatocellular carcinoma (HepG-2), epithelioid cervical carcinoma (HeLa) and mammary gland breast cancer (MCF-7) cell lines.
Antiproliferative agent-18 occupies the positions of NAD cofactor and the histone deacetylase inhibitor EX527 at the active site of SIRT1 enzyme.
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文献和实验One of the more intriguing features of the hemopoietic system is the ability of a single phenotypically homogeneous stem cell to give rise—through differentiation and development—to all the phenotypically diverse mature immuno-hemopoietic
compounds and for the derivation of IC50 values. IC50 value is defined as the concentration of a test compound required to achieve half maximal inhibition of methyl-[3H]-thymidine incorporation, a parameter that is indicative of antiproliferative potency. IC
Functional Analysis of the Antimitogenic Activity of Tumor Suppressors
Loss of tumor suppressors contributes to numerous cancer types. Many, but not all, proteins encoded by tumor suppressor genes have antiproliferative activity and halt cell-cycle progression. In this chapter, we present three methods
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