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- Sino Biological
- 10150-MM09
- 2025年08月12日
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100 µL
抗体种属：Human
抗体靶点：CDH6
抗体应用：ELISA
抗原货号：10150-H08H
抗原描述：Recombinant Human K Cadherin / CDH6 Protein (Catalog#10150-H08H)
抗体宿主：Mouse
抗体Ig类型：Mouse IgG1
抗体纯化方法：Protein A
抗体制备：This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human K Cadherin / CDH6 (rh K Cadherin / CDH6; Catalog#10150-H08H; NP_004923.1; Met1-Ala615). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
抗体特异性：Human K Cadherin / CDH6
抗体保存：This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.
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文献和实验- Placental (P-cadherin) (CDH3). - Retinal (R-cadherin) (CDH4). - Vascular endothelial (VE-cadherin) (CDH5). - Kidney (K-cadherin) (CDH6). - Cadherin-8 (CDH8). - Osteoblast (OB-cadherin) (CDH11). - Brain (BR-cadherin) (CDH12). - T-cadherin
either induced the expression of an endothelial-specific differentiation marker, VE-cadherin, in non-endothelial cell lines or, when combined with a repression domain, knocked down expression. Potential binding sites for a number of these transcription factors
FRAT1 的表达，从而促进β-catenin 的降解，抑制其核内定位。β-catenin 降解的抑制及核内定位的增加是 Wnt/β-catenin 信号通路的激活的关键步骤，miR-490-3p 能够通过靶向调控 FRAT1 的表达，促进β-catenin 的降解和抑制其核内定位，从而介导 Wnt/β-catenin 信号通路的活性，最终影响结直肠癌的转移。该研究结果为阐明结直肠癌发生发展的机制提供有力的科学依据。 原文出处：Zheng K, Zhou X, Yu J, et
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