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NIR-βgal-2
MCE 国际站：NIR-βgal-2
产品活性：NIR-βgal-2 是一种 β-半乳糖苷酶激活的近红外荧光探针，具有优异的灵敏度。NIR-βgal-2 可用于可视化乳腺癌中的 β-半乳糖苷酶。
研究领域：Others
作用靶点：Fluorescent Dye
In Vitro: NIR-βgal-2 displays superior sensitivity (detection limit = 2.0 × 10-3 U/mL), great affinity (Km = 1.84 μM), and catalytic efficiency (kcat/Km = 0.24 μM-1 s-1) for β-galactosidase.
The survival rate of cells (SKOV-3, 4T1, A549, and L02 cells) in the presence of NIR-βgal-2 is higher than 80% after 24 h, suggesting that the probe had low cytotoxicity toward the cells.
Human ovarian carcinoma cells (SKOV-3 cells) and mouse breast cancer cells (4T1 cells) that endogenously overexpress β-galactosidase are chosen as cell models for this study. In comparison, human normal liver cells (L02 cells) and human lung cancer cells (A549 cells) are selected as negative groups. After incubating with NIR-βgal-2 (5 μM) for 30 min, can observe bright fluorescence signals in SKOV-3 and 4T1 cells, whereas faint NIR fluorescence is observed in A549 and L02 cells. NIR-βgal-2 could differentiate efficiently and rapidly detect β-galactosidase in different cells and can distinguish cancer cells that overexpress β-galactosidase.
In Vivo: NIR-βgal-2 (tumor injection; 100 μM/25 μL; 0, 10, 20, 30, and 60 min; Ex=640 nm, Em=695-770 nm) observes an intense signal in the tumor area in 4T1-bearing mice.
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文献和实验MicroPET, MicroSPECT, and NIR Fluorescence Imaging of Biomolecules In Vivo
and quantifying the receptor expression in vivo by means of microPET, microSPECT, and NIR fluorescence.
1. 近红外荧光 / 光声双模态成像小知识 荧光成像凭借高时空分辨率、高灵敏度等优势广泛用于生物医学研究，其中近红外成像因穿透深、光毒性低、组织自发荧光干扰小，成为肿瘤诊疗研究热点。荧光纳米探针可调控组分尺寸实现近红外成像，还可修饰赋予靶向、载药、多模态检测能力。[29] 传统探针多工作于可见光与第一近红外区（400-900 nm），受穿透深度、空间分辨率限制，应用受限。第二近红外区 NIR-II（1000-1700 nm）光散射弱、背景荧光低，适合深层组织成像，但单一荧光模态仍难以兼顾活体
and abdominal autofluorescence detected by in vivo fluorescence imaging of living mice. Mol Imaging. 2008 Jan-Feb;7(1):21-7.) 上图为测定每种食物颗粒的荧光强度。纯化饲料（purified diet）在绿色区域荧光最强，其次是无苜蓿饲料（Alfalfa-free diet）和常规饲料（regular diet）。相比之下，远红光和 NIR 区荧光最强的是常规饲料，无苜蓿饲料荧光较弱，纯化饲料荧
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