Diprovocim,2170867-89-5

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Diprovocim

CAS No. : 2170867-89-5

MCE 国际站：Diprovocim

产品活性：Diprovocim 是一种有效的 TLR1/TLR2 激动剂。Diprovocim 在人 THP-1 细胞中引发完全激动剂活性 (EC₅₀=110 pM)。Diprovocim 刺激小鼠巨噬细胞释放 TNF-α (EC₅₀=1.3 nM)。Diprovocim 激活下游 MAPK 和 NF-κB 信号通路。Diprovocim 在小鼠中显示出很强的佐剂活性，尤其是促进细胞免疫反应。

研究领域：Immunology/Inflammation  |  Apoptosis  |  MAPK/ERK Pathway  |  NF-κB

作用靶点：Toll-like Receptor (TLR)  |  TNF Receptor  |  p38 MAPK  |  NF-κB

In Vitro: Diprovocim (5 nM in THP-1 and 500 nM in mouse peritoneal macrophage; 15-120 mins) induces phosphorylation of IKKα, IKKβ, p38, JNK, and ERK, as well as degradation of IκBα in THP-1 cells and mouse peritoneal macrophages.
Diprovocim (0.01-10000 nM; 4 hours) induces dose-dependent TNF production by THP-1 cells (EC₅₀=110 pM) and human peripheral blood mononuclear cells (PBMC) (EC₅₀=875 pM) and by mouse peritoneal macrophages (EC₅₀=1.3 nM) and bone marrow-derived dendritic cells (BMDC) (EC₅₀=6.7 nM). In addition to TNF, Diprovocim induced IL-6 production by mouse BMDC.

In Vivo: Diprovocim (10 mg/kg) uses as an adjuvant and mixed with ovalbumin (OVA; 100 μg) by i.m. induces similar levels of serum OVA-specific IgG after 14 days.
Diprovocim (10 mg/kg; i.m.) mixed with ovalbumin (OVA; 100 μg) before inoculation with B16-OVA cells immunizes significantly slows tumor growth rate but failed to prolong survival relative to OVA alone after 7 days.

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