STING-IN-4,2250374-27-5

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STING-IN-4

CAS No. : 2250374-27-5

MCE 国际站：STING-IN-4

产品活性：STING-IN-4 (Compound 1) 是一种 STING 抑制剂，抑制 STING 的表达，从而降低 STING 和核因子-κB (NF-κB) 信号通路的激活。STING-IN-4 具有抗炎活性，可用于脓毒症的研究。

研究领域：Immunology/Inflammation

作用靶点：STING

In Vitro: STING-IN-4 (Compound 1) (20 μM; 26 h) inhibits NO production induced by LPS in RAW264.7 cells.
STING-IN-4 (2.5-10 μM; 26 h) significantly inhibits the expression of iNOS in RAW264.7 cells.
STING-IN-4 (5 and 50 μM; 12 h) significantly reduces STING degradation at 49, 52, and 55 °C and it may have an ability to interact with STING and enhance thermal stabilization of STING.
STING-IN-4 (2.5-10 μM; 8 h) inhibits LPS-induced activation of STING/IRF3/NF-κB.

In Vivo: STING-IN-4 (Compound 1) (1-9 mg/kg; i.p.; daily for 3 days) protects against LPS-induced liver injuries in mice and inhibits STING/IRF3/NF-κB activation in septic mice livers.

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