SMANT,1177600-74-6

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SMANT hydrochloride

CAS No. : 1177600-74-6

MCE 国际站：SMANT hydrochloride

产品活性：SMANT hydrochloride 是一种 Smoothened (Smo) 信号抑制剂。SMANT hydrochloride 是初级纤毛 (PC) 内 Smo 积累的拮抗剂。SMANT hydrochloride 在抑制 SmoM2 (Smo 的致癌形式) 和野生型 Smo 方面具有同等活性。

研究领域：Stem Cell/Wnt

作用靶点：Smo  |  Hedgehog

In Vitro: SMANT (0-10 μM, NIH/3T3 cells) hydrochloride inhibits Hh induced Smo accumulation at the primary cilium (IC₅₀: 1.1 μM).
SMANT (0-10 μM, NIH/3T3 cells) hydrochloride inhibits Smo and SmoM2 activity, and blocks the stimulatory action of SAG in Gli-luciferase assay.
SMANT (0-10 μM) hydrochloride inhibits proliferation of cerebellar granule-cell neural progenitors (CGNP) (isolated from Ptch1^+/− neonates) induced by Shh.

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