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CUR61414
CAS No. : 334998-36-6
MCE 国际站：CUR61414
产品活性：CUR61414 是一种新型的可渗透细胞的 Hedgehog 信号通路抑制剂 (IC50 =100-200 nM)，CUR61414 是氨基脯氨酸类化合物的小分子成员，可选择性结合 Smoothened (Smo)，Ki 值为 44 nM。CUR-61414可以诱导癌细胞凋亡 (apoptosis) 而不会影响非癌症细胞。
研究领域：Stem Cell/Wnt | Apoptosis
作用靶点：Hedgehog | Smo | Apoptosis
In Vitro: CUR61414 is able to arrest proliferation of basal cells within the BCC-like lesions and induce cells to undergo apoptosis resulting in complete regression of the lesions, without affecting neighboring skin cells.
In Vivo: CUR61414 cause regression of these lesions in the mice, which are exposed to UV light irradiation for 6-9 months, producing many microscopic BCC-like basaloid lesions throughout their skin. Moreover,a significant increase in apoptotic nuclei can be seen in basaloid nests after CUR61414 treatment and no overt toxicity is observed in the skin surrounding the lesions.
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文献和实验. Cut away the molecular weight marker lane and shake it in TBST for 30 minutes (or longer). The rest of the membrane may be sliced in strips, if needed. For a 10 well comb, each well may be cur in half. Notch the left bottom edge of all strips
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