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Hydrochlorothiazide
CAS No. : 58-93-5
MCE 国际站：Hydrochlorothiazide
产品活性：Hydrochlorothiazide (HCTZ) 是一种口服有效的噻嗪类的利尿药，可抑制转化 TGF-β/Smad 信号通路。Hydrochlorothiazide 通过打开钙激活钾 (KCA) 通道具有直接的血管松弛作用。Hydrochlorothiazide 改善心脏功能，减少纤维化并具有降压作用。
研究领域：Stem Cell/Wnt | TGF-beta/Smad | Membrane Transporter/Ion Channel
作用靶点：TGF-beta/Smad | Potassium Channel
In Vitro: Hydrochlorothiazide belongs to thiazide class of diuretics. It reduces blood volume by acting on the kidneys to reduce sodium (Na) reabsorption in the distal convoluted tubule. The major site of action in the nephron appears on an electroneutral Na+-Cl co-transporter by competing for the chloride site on the transporter. By impairing Na transport in the distal convoluted tubule, hydrochlorothiazide induces a natriuresis and concomitant water loss. Thiazides increase the reabsorption of calcium in this segment in a manner unrelated to sodium transport. Additionally, by other mechanisms, Hydrochlorothiazide is believed to lower peripheral vascular resistance.
In Vivo: Hydrochlorothiazide (HCTZ; orally bygavage; 12.5 mg/kg/d; 8 weeks) has improved cardiac function, reduced cardiac interstitial fibrosis and collagen volume fraction, decreased expression of AT1, TGF-β and Smad2 in the cardiac tissues in adult male Sprague Dawley rats. In addition, hydrochlorothiazide reduces plasma angiotensin II and aldosterone levels. Furthermore, hydrochlorothiazide inhibits angiotensin II-induced TGF-β1 and Smad2 protein expression in the neonatal rat ventricular fibroblasts.
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文献和实验控制。 【关键词】 氢氯噻嗪 高效液相色谱法 含量测定 HPLC Determination of Hydrochlorothiazide ZENG Tan, ZHOU Lin (Chongqing Institute for Drug Control, Chongqing 400121, China) ［Abstract］ Objective:To develop an HPLC method for the determination
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