- ￥2045 - 4500
- MedChemExpress(MCE)
- 美国
- HY-148365
- 2025年12月05日
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 技术资料
- 保存条件：
4°C, sealed storage, away from moisture
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- 规格：
10 mM * 1 mL/1 mg/5 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥ |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥2045.0 |
| 规格： | 5 mg | 产品价格： | ￥4500.0 |
MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。
NecroIr1
MCE 国际站：NecroIr1
产品活性：NecroIr1 是一种铱 (III) 复合物，是顺铂 (Cisplatin, HY-17394) 耐药肺癌细胞 (A549R) 的坏死诱导剂。NecroIr1 选择性积累在线粒体中，导致氧化应激和线粒体膜电位 (MMP) 的损失。NecroIr1 能够激活受体相互作用的丝氨酸苏氨酸激酶 3 (RIPK3) 和混合谱系激酶结构域样假激酶 (MLKL)，调节 CDK4 表达。
研究领域：MAPK/ERK Pathway | Apoptosis | Cell Cycle/DNA Damage
作用靶点：Mixed Lineage Kinase | RIP kinase | CDK
In Vitro: NecroIr1 (2 μM; 1-2 d) exerts subcellular distribution over 90% accumulated in mitochondria in non-labelled A549R and CFSElabelled L02 cells.
NecroIr1 (1.5 μM and 3 μM; 24 h) results ROS generation increasing and loss of mitochondrial membrane potential.
NecroIr1 (1.5 μM and 3 μM; 24 h) activates necroptosis proteins, increases the phosphorylation of RIPK1 and RIPK3.
NecroIr1 (0.75 μM and 1.5 μM; 24 h) induces necroptosis by arresting cell cycle at G0/G1.
NecroIr1 (0.75-3.0 μM; 24 h) inhibits A549R cells proliferation.
相关产品：Bioactive Compound Library Plus | Apoptosis Compound Library | Cell Cycle/DNA Damage Compound Library | Immunology/Inflammation Compound Library | Kinase Inhibitor Library | MAPK Compound Library | NF-κB Signaling Compound Library | Anti-Cancer Compound Library | Anti-Aging Compound Library | Oxygen Sensing Compound Library | Anti-Breast Cancer Compound Library | Anti-Lung Cancer Compound Library | Anti-Pancreatic Cancer Compound Library | Anti-Blood Cancer Compound Library | Anti-Parkinson's Disease Compound Library | Neurodegenerative Disease-related Compound Library | Protein-protein Interaction Inhibitor Library | Cancer Stem Cells Compound Library | Membrane Protein-targeted Compound Library | Highly Selective Inhibitors Library | Highly Selective Activators Library | Serine/Threonine Kinase Inhibitor Library | Necrostatin-1 | Palbociclib | Abemaciclib | Necrosulfonamide | Ro-3306 | Ribociclib | Dinaciclib | GSK-872 | GSK3326595 | THZ1 | Flavopiridol | SR-4835 | (R)-Roscovitine | THZ531 | AZD4573 | Necrostatin 2 racemate | SY-5609 | Kenpaullone | Wogonin | SNS-032 | GSK 3 Inhibitor IX | Cirtuvivint | NVP-2 | Toyocamycin | Fadraciclib | Simurosertib | AT7519
热门产品线：重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物
Trending products：Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Dye Reagents | PROTAC | Isotope-Labeled Compounds
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
技术资料暂无技术资料 索取技术资料
