- ￥2720 - 21500
- TargetMol
- 美国
- T11704
- 2025年07月12日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
零下80~20°C
- 保质期：
Powder: -20°C for 3 years In solvent: -80°C for 2 years
- 英文名：
JAK-IN-3
- 库存：
10
- 供应商：
TargetMol
- CAS号：
1400876-94-9
- 规格：
2 mg/50 mg/100 mg/25 mg
| 规格： | 2 mg | 产品价格： | ￥2720.0 |
|---|---|---|---|
| 规格： | 50 mg | 产品价格： | ￥16800.0 |
| 规格： | 100 mg | 产品价格： | ￥21500.0 |
| 规格： | 25 mg | 产品价格： | ￥12800.0 |
Product Introduction
Bioactivity
英文名:JAK-IN-3
描述:JAK-IN-3 is a potent JAK inhibitor, with IC50 values of 3 nM, 5 nM, 34 nM and 70 nM for JAK3, JAK1, TYK2 and JAK2, respectively.
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文献和实验Recently, a point mutation in the JAK2 gene, JAK2 V617F , was discovered in several myeloid proliferative neoplasms including polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF). Demonstration
Production and Crystallization of Recombinant JAK Proteins
JAK kinases are critical mediators in development, differentiation, and homeostasis and accordingly, have become well-validated targets for drug discovery efforts. In recent years, the integration of X-ray crystallography in kinase-focused
In Vitro JAK Kinase Activity and Inhibition Assays
The discovery that a range of myeloproliferative diseases and leukemias are associated with Janus Kinase (JAK) mutations has highlighted the importance of JAK/STAT signalling in disease and sparked a renewed interest in developing JAK
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