- ￥1500 - 2300
- 爱必信(absin)
- abs136038
- 上海
- 2025年07月15日
- -
- -
- -
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 文献和实验
- 技术资料
- 抗体名：
HMGCR抗体
- 抗体英文名：
-
- 靶点：
-
- 浓度：
-
- 应用范围：
-
- 宿主：
-
- 适应物种：
-
- 保质期：
-
- 抗原来源：
-
- 目录编号：
-
- 级别：
-
- 库存：
现货
- 供应商：
爱必信(上海)生物科技有限公司
- 标记物：
-
- 克隆性：
-
- 保存条件：
Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
- 形态：
-
- 亚型：
-
- 免疫原：
-
- 规格：
50ug/100ug
| 规格： | 50ug | 产品价格： | ￥1500.0 |
|---|---|---|---|
| 规格： | 100ug | 产品价格： | ￥2300.0 |
| 描述 | HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008] |
| 别名 | HMGCR抗体;3 hydroxy 3 methylglutaryl CoA reductase, 3 hydroxy 3 methylglutaryl Coenzyme A reductase, 3 hydroxymethylglutaryl CoA reductase, 3-hydroxy-3-methylglutaryl CoA reductase (NADPH), 3-hydroxy-3-methylglutaryl-coenzyme A reductase, 3H3M, HMDH_HUMAN, HMG CoA reductase, HMG CoAR, HMG-CoA reductase, Hmgcr, Hydroxymethylglutaryl CoA reductase, LDLCQ3, MGC103269, Red, |
| 宿主 | Rabbit |
| 特异性 | HMGCR Antibody detects endogenous levels of total HMGCR. |
| 反应种属 | Human;Mouse;Rat |
| 预测反应种属 | Bovine;Horse; |
| 应用 | WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000 |
| 分子量 | Predicted molecular weight: 97kD Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. |
| 免疫原 | A synthesized peptide derived from Human HMGCR(Accession P04035), corresponding to amino acid residues C30-D56. |
| 浓度 | 1mg/ml |
| 纯化方法 | The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin . |
| 类型 | Polyclonal Antibody |
| 储存/保存方法 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles |
| 存储溶液 | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt. |
| 背景说明 | Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins. |
| 翻译后修饰 | N-glycosylated. Deglycosylated by NGLY1 on release from the endoplasmic reticulum (ER) in a sterol-mediated manner.Undergoes sterol-mediated ubiquitination and ER-association degradation (ERAD). Accumulation of sterols in the endoplasmic reticulum (ER) membrane, triggers binding of the reductase to the ER membrane protein INSIG1. This INSIG1 binding leads to the recruitment of the ubiquitin ligase, AMFR/gp78, initiating ubiquitination of the reductase. The ubiquitinated reductase is then extracted from the ER membrane and delivered to cytosolic 26S proteosomes by a mechanism probably mediated by the ATPase Valosin-containing protein VCP/p97. Lys-248 is the main site of ubiquitination. Ubiquitination is enhanced by the presence of a geranylgeranylated protein. |
| 细胞定位 | Endoplasmic reticulum;Peroxisome; |
| UniProt | P04035 |
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验- 6-Gingerol Regulates Hepatic Cholesterol Metabolism by Up-regulation of LDLR and Cholesterol Efflux-Related Genes in HepG2 Cells Xiao Li,Jingting Guo,Ning Liang,Xinwei Jiang,Yuan Song,Shiyi Ou,Yunfeng Hu,Rui Jiao,Weibin Bai
Front Pharmacol. 2018 Feb 27 .
影响因子： 3.831
Immunofluorescence: Rabbit Anti-Murine RELMα
for 25 minutes. 3. Incubate the tissue section with blocking buffer for 20 minutes. 4. Incubate the tissue section overnight at 4?C with Rabbit Anti-Murine RELMα at 4.0 ng/mL in 1X PBS with 0.01% Triton-X and 0.5% BSA. Wash the slide
抗核抗体(anti-nucleic antibody，ANA)检测
抗核抗体(anti-nucleic antibody，ANA)是以真核细胞的核成分为靶抗原的自身抗体的总称。细胞核内含有许多不同成分如核蛋白、核糖核蛋白(ribonucleo protein，RNP)、脱氧核糖核酸(DNA)等。 在某些因素，如细菌、病毒、药物等作用下，可改变细胞核某些成分的性质，激发机体免疫系统产生许多抗不同核成分的抗体。
Polyclonal Antibody Production
Zealand White Rabbits and have them delivered to the ARC. Don’t put all your eggs in one basket only using one rabbit. Let them get accustomed to there home there for two weeks before the first pre-bleed. Pre-bleed
技术资料暂无技术资料 索取技术资料
