Emapticap pegol,1390630-22-4

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Emapticap pegol

CAS No. : 1390630-22-4

MCE 国际站：Emapticap pegol

产品活性：Emapticap pegol 是促炎趋化因子 C-C 基序配体 2 (CCL2) 的抑制剂。Emapticap pegol 是一种 40 个核苷酸的寡核苷酸适体，在人 (NOX-E36) 和小鼠 (mNOX-E36) 中具有不同的 Spiegelmers (L-RNA 适配子) 形式。

研究领域：Others

作用靶点：Others

In Vitro: Spiegelmers are RNA-like molecules built from L-ribose units that are able to bind molecules such as peptides and proteins. NOX-E36, is human-specific CCL2 Spiegelmer; and mNOX-E36, is the mouse-specific CCL2 Spiegelmer.
NOX-E36 (1 nM) significantly inhibits CCL2-mediated migration in human monocytic leukemia cell line THP-1.
NOX-E36 inhibits monocyte chemotactic protein-1 (MCP-1), and blocks the inflammatory cell recruitment and differentiation of macrophages mediated by MCP-1.
mNOX-E36 inhibits the migration and signaling pathway activation in murine hematopoietic cells, and blocks CCL2 receptor expressing Ba/F3 cells (Ba/F3-CCR2) migration (~2000 fold than normal migration) in a dose-dependent manner.
mNOX-E36 abrogates the phosphorylation induced by CCL2 of AKT, ERK, p35-MAPK, respectively in mCCL2-stimulated cells (30 min).

In Vivo: Emapticap pegol (14.4 mg/kg, mNOX-E36; s.c.; three times per week, for 3 weeks) interferes the infiltration of M2-like macrophages into spleens of leukemia-bearing mice.
Emapticap pegol (20 mg/kg, mNOX-E36; s.c.; three times per week, for 4 weeks) reduces albuminuria and restores the glomerular endothelial glycocalyx in diabetic mice.

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