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- 2025年07月10日
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Please store the product under the recommended conditions in the Certificate of Analysis.
- 英文名：
McN 4853 lithium; RWJ 17021 lithium
- 库存：
货期：电询
- 供应商：
MedChemExpress LLC
- CAS号：
488127-53-3
- 规格：
电询
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Topiramate lithium
CAS No. : 488127-53-3
MCE 国际站：Topiramate lithium
产品活性：Topiramate (McN 4853) lithium 是一种广谱抗癫痫剂。Topiramate lithium 也是一种 GluR5 受体拮抗剂，可通过增强 GABAergic 活性，抑制 kainate/AMPA 受体，抑制钠和钙通道的电压敏感，增加钾电导并抑制 carbonic anhydrase 来产生抗癫痫作用。
研究领域：Membrane Transporter/Ion Channel | Neuronal Signaling | Metabolic Enzyme/Protease
作用靶点：iGluR | GABA Receptor | Sodium Channel | Calcium Channel | Potassium Channel | Carbonic Anhydrase
In Vitro: Topiramate lithium has been believed to be a type of antiepileptic drug that blocks spread of seizures. Thus far, the mechanisms of its actions have been proven to include use-dependent inhibition of voltage-dependent Na+ channels in neurons, potentiation of GABA (γ-amino-butyric acid)-induced Cl- influx, and inhibitory effects on inward currents by antagonizing kainate/alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptors.
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文献和实验Abstract Previous studies by Stachel and colleagues indicate that lithium chloride induction of post-midblastular Brachydanio rerio embryos results in deficiencies in normal anterior-posterior development. To determine
DEVELOPMENTAL EFFECTS OF LITHIUM CHLORIDE ON XENOPUS EMBRYOS
PURPOSE: The objective of this experiment is to study the effect of lithium chloride treatment on early blastula xenopus embryos. INTRODUCTION: When the developing embryos of many organisms, such as the lytechinus variegatus (sea urchin
The effect of lithium chloride on Lytechinus variegates embryos
Purpose This experiment will study effects of lithium chloride on sea urchin development, forcusing on archenteron formation. Introduction Gastrulation is extensive cell rearrangement where cells undergo dramatic movements
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