SphK1-IN-2,3031483-60-7

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SphK1-IN-2

CAS No. :

MCE 国际站：SphK1-IN-2

产品活性：SphK1-IN-2 是一种有效的选择性 SphK1 抑制剂，SphK1 和 SphK2 的 IC₅₀ 值分别为 19.81 nM和 ＞10 μM。SphK1-IN-2 具有抗增殖活性，诱导细胞周期阻滞和凋亡 (apoptosis)。SphK1-IN-2 可用于癌症研究。

研究领域：Immunology/Inflammation  |  Apoptosis

作用靶点：SphK  |  Apoptosis

In Vitro: SphK1-IN-2 (4-24 μM; 72 hours; cancer cell lines) has anti-proliferative activity on cancer cells.
SphK1-IN-2 (10-30 μM; 48 hours; HT-29 cells and MDA-MB-231 cells) induces G0/G1 phase arrest and apoptosis in colon cancer cells.

In Vivo: SphK1-IN-2 (50-100 mg/kg; i.p.; daily; for 14 days; female BALB/c nude mice) inhibits the growth of colon tumors and breast tumors in vivo.
SphK1-IN-2 (2-50 mg/kg; p.o., i.p. and i.v.; female BALB/c nude mice) exhibits a long half-life (T_1/2=8.13 h) and high plasma exposure (AUC_last = 8061 h*ng/mL).

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