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Anti-Integrin Alpha V + Beta 3 (CD51+CD61)
Integrin Alpha V + Beta 3 (CD51+CD61) 抗体
详询
兔
/
见产品详情
IgG
Lyophilized or Liquid
见产品详情
-20℃
1mg/ml
详询
英文名称 Anti-Integrin Alpha V + Beta 3 (CD51+CD61) |
中文名称 整合素αVβ3抗体 |
别 名 CD51 + CD61; CD51; CD61; GP3A; GPIIIa; integrin alpha v; integrin beta 3; intregrin alpha v beta 3; ITGAV; ITGB3; Platelet membrane glycoprotein IIIa; Vitronectin receptor alpha subunit; VNRA; Antigen identified by monoclonal antibody L230; CD51 antigen; CD61 antigen; DKFZp686A08142; Integrin alpha V (vitronectin receptor, alpha polypeptide, antigen CD51); integrin alpha v; Integrin beta 3 (platelet glycoprotein IIIa, antigen CD61); Integrin beta chain beta 3; intregrin alpha v beta 3; ITGAV; MSK8; Platelet glycoprotein IIIa; Platelet membrane glycoprotein IIIa; Vitronectin receptor alpha subunit; Vitronectin receptor subunit alpha. |
浓 度 1mg/1ml |
规 格 0.2ml/200μg 1ml/1mg |
抗体来源 Rabbit |
克隆类型 polyclonal |
交叉反应 Human, Mouse, Rat |
产品类型 一抗 |
研究领域 细胞生物 免疫学 信号转导 干细胞 细胞粘附分子 |
性 状 Lyophilized or Liquid |
免 疫 原 KLH conjugated synthetic peptide derived from human Integrin Alpha V + Beta 3 |
亚 型 IgG |
纯化方法 affinity purified by Protein A |
储 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide |
产品应用 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:100-500 IF=1:100-500 |
(石蜡切片需做抗原修复) |
not yet tested in other applications. |
optimal dilutions/concentrations should be determined by the end user. |
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
产品介绍 Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. They are known to participate in cell adhesion as well as cell-surface mediated signalling. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. |
CD51 encodes integrin alpha chain V. The I-domain containing integrin alpha V undergoes post-translational cleavage to yield disulfide-linked heavy and light chains, that combine with multiple integrin beta chains to form different integrins. The CD61 protein product is the integrin beta chain beta 3. Integrin beta 3 is found along with the alpha IIb chain in platelets. |
Integrin alpha V/beta 3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase 2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha V/beta 3 recognizes the sequence R-G-D in a wide array of ligands. The alpha V integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase 2, osteopontin, osteomodulin, prothrombin, thrombospondin and von Willebrand factor. They recognize the sequence R-G-D in a wide array of ligands. |
整合素αVβ3为二聚体的跨膜糖蛋白质,可以调节肿瘤细胞在多种细胞外基质蛋白中的粘附和迁移,在被激活的内皮细胞中有较高的表达,并在新生血管生成过程中发挥优势。 |
整合素αVβ3在细胞外的信号传入细胞内调节细胞生长、改变细胞形态、影响细胞运动, 并在肿瘤侵袭和转移的过程中起重要作用.整合素αVβ3是特异性表达在血管内皮细胞表面的粘附因子。 |
OGP (Ostegenic Growth Peptide) 成骨生长肽 (骨生长激素肽)(多肽) |
OPN 骨桥蛋白(多肽抗原) |
P53 肿瘤抑制基因(抗原) |
PACAP-27/38 腺苷酸环化酶激活肽-27/38(抗原) |
PACAP-38 腺苷酸环化酶激活肽-38(抗原) |
PACAP/VIP receptor 腺苷酸环化酶激活肽/血管活性肠肽受体(抗原) |
PACAP receptor-I 腺苷酸环化酶激活肽受体(抗原) |
PADI4 (HL-60 PAD)(Protein-arginine deiminase type IV,PADI 4,PAD I4 ) 关节炎相关基因 |
PDGF-A 血小板源性生长因子-1(抗原) |
PDGF-B 血小板源性生长因子-B(抗原) |
PDGF-R-A 血小板源性生长因子受体-A(抗原) |
PDGF-R-B 血小板源性生长因子受体-B(抗原) |
PMP-22(Peripheral Myelin Protein) 外周髓鞘蛋白-22 多肽 |
PI3K 磷脂酰肌醇激酶(抗原) |
PLGF (Placenta growth factor) 小鼠胎盘生长因子(多肽抗原) |
PLGF (Placenta growth factor) 胎盘生长因子(多肽抗原) |
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