相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 文献和实验
- 技术资料
- 供应商:
优利科(上海)生命科学有限公司
- 库存:
100
- 靶点:
/
- 级别:
科研
- 目录编号:
/
- 克隆性:
多克隆
- 抗原来源:
详见说明书
- 保质期:
1年
- 抗体英文名:
Anti-IL-1R1/CD121a/IL1 Receptor I
- 抗体名:
IL-1R1/CD121a/IL1 Receptor I抗体
- 标记物:
详询
- 宿主:
兔
- 适应物种:
/
- 免疫原:
见产品详情
- 亚型:
IgG
- 形态:
Lyophilized or Liquid
- 应用范围:
见产品详情
- 保存条件:
-20℃
- 浓度:
1mg/ml
- 规格:
详询
| 英文名称 Anti-IL-1R1/CD121a/IL1 Receptor I |
| 中文名称 白介素1受体1抗体 |
| 别 名 Antigen CD121a; CD121 antigen-like family member A; CD121A; CD121a antigen; D2S1473; IL 1; IL 1R 1; IL 1R alpha; IL 1RT1; IL-1R-1; IL-1R-alpha; IL-1RT-1; IL-1RT1; IL1 inhibitor; IL1R; IL1R1; IL1R1_HUMAN; IL1RA; IL1RN; IL1RT1; Interleukin 1 receptor alpha type 1; Interleukin 1 receptor antagonist protein (IRAP); Interleukin 1 receptor type I; Interleukin receptor 1; Interleukin-1 receptor alpha; Interleukin-1 receptor type 1; Interleukin-1 receptor type I; P80. |
| 浓 度 1mg/1ml |
| 规 格 0.1ml/100μg 0.2ml/200μg |
| 抗体来源 Rabbit |
| 克隆类型 polyclonal |
| 交叉反应 Human, Mouse, Rat |
| 产品类型 一抗 |
研究领域 心血管 免疫学 干细胞 淋巴细胞 t-淋巴细胞 细胞因子 ![]() |
| 蛋白分子量 predicted molecular weight: 63kDa |
| 性 状 Lyophilized or Liquid |
| 免 疫 原 KLH conjugated synthetic peptide derived from human IL-1R1 C-terminus |
| 亚 型 IgG |
| 纯化方法 affinity purified by Protein A |
| 储 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide |
| 产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:100-500 ICC=1:100-500 IF=1:100-500 |
| (石蜡切片需做抗原修复) |
| not yet tested in other applications. |
| optimal dilutions/concentrations should be determined by the end user. |
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. ![]() |
| Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 产品介绍 The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein is a receptor for interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA). It is an important mediator involved in many cytokine induced immune and inflammatory responses. This gene along with interleukin 1 receptor, type II(IL1R2), interleukin 1 receptor-like 2 (IL1RL2), and interleukin 1 receptor-like 1 (IL1RL1) form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. [provided by RefSeq]. |
| Function : Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the corecptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. |
| Subunit : The interleukin-1 receptor complex is a heterodimer of IL1R1 and IL1RAP. |
| Subcellular Location : Membrane; Single-pass type I membrane protein. Cell membrane (Probable). Secreted. |
| Post-translational modifications : A soluble form (sIL1R1) is probably produced by proteolytic cleavage at the cell surface (shedding). |
| Similarity : Belongs to the interleukin-1 receptor family. |
| Contains 3 Ig-like C2-type (immunoglobulin-like) domains. |
| Contains 1 TIR domain. |
| Database links : UniProtKB/Swiss-Prot: P14778.1 |
IL-1RⅠ属于新的信号受体家族Toll信号转导通路蛋白,IL-1RⅠ在免疫和炎症反应的研究中占重要地位,是在很多感染 、炎症性致病机制中起决定性作用的细胞因子,几乎可作用于全身各种细胞,IL-1 与IL-1R1的结合可导致大量与免疫反应和炎症相关基因的表达 ,包括细胞因子、细胞因子受体、急性期反应物、生长因子、胞外基质、粘附分子等。IL-1R1/NF-κB信号通路是机体免疫反应中十分重要的组成部分。白介素1受体I型 Interleukin 1 receptor I(IL-1RI) ![]() |
| MMP-1(Mous ematrix metalloproteinases-1) 基质金属蛋白酶-1(小鼠抗原) |
| midnolin isoform Protein 1 中脑核仁蛋白1(抗原) |
| midnolin isoform Protein 2 中脑核仁蛋白2(抗原) |
| MICA(MHC class I polypeptide-related sequence A) 一种细胞应激分子抗原 |
| MRP3(Multidrug Resistanec-Associated Protein 3) 多药耐药相关蛋白3(抗原) |
| MRP1(Multidrug Resistanec-Associated Protein 1) 多药耐药相关蛋白1(抗原) |
| LRP/MVP (Lung resistance related protein) 肺耐药相关蛋白(抗原) |
| MSLN(mesothelin) 间皮素(多肽抗原) |
| MSH2 (mutS homolog 2) MSH2抗原 |
| NKR(Neuromedin B Receptor) 神经激肽B受体(抗原) |
| NF-L(Neurofilament triplet L) 低分子量神经丝蛋白(抗原) |
| NF-M (Neurofilament triplet M) 中分子量神经丝蛋白(抗原) |
| NF-H(Neurofilament triplet H) 高分子量神经丝蛋白(抗原) |
| NIS(Na+/I-symporter;NIS) 钠碘转运体蛋白(多肽抗原) |
风险提示:丁香通仅作为第三方平台,为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全,合理判断,谨慎选购商品,商家和用户对交易行为负责。对于医疗器械类产品,请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验免疫球蛋白样转录体受体 免疫球蛋白样转录体(Ig―like transcrlpts,ILTs)作为受体,含有杀伤细胞免疫球蛋白样功能区,其胞质区含4个ITIM。ILTs的成员ILT-2对HLAI类分子有较广的特异性,主要结合I类分子3结构域以及HLAI类分子的同源体――UL18,一种巨细胞病毒编码的分子。这可能代表着病毒的一种诱骗机制,通过与抑制受体结合,使之免遭NK细胞介导的攻击和杀伤。 激活性受体的研究比较滞后,最近
常用实验动物,其LC的许多表面标记与人LC相似。 现今认为,皮肤是一个具有独特免疫功能的器官,与机体免疫系统密切相关。而LC有多种免疫功能。除上述与免疫相关的一些表面标记外,LC能摄取,提呈抗原,具有同种异基因刺激作用,还可分泌白介素1等细胞因子。LC在接触性变态反应和移植排斥过程中均起重要作用。 免疫细胞化学技术在与LC相关研究中的应用。 一、研究LC自身的表面标记 应用免疫细胞化学技术进一步研究LC表面受体或表面分子,以加深对LC功能
抗肝肾微粒体抗体(LKM)是一种自身抗体。是诊断II型自身免疫性肝炎的血清学指标,靶抗原为LKM-1(细胞色素P450IID6)、LKM-2、LKM-3和肝微粒体。 自身免疫性肝炎按血清学标志至少可分为三型:Ⅰ型(“狼疮样”肝炎)以出现抗核抗体(ANA)、平滑肌抗体(ASMA)、肝细胞膜抗体(LMA抗体)为特征;Ⅱ型以出现LKM抗体为特征;Ⅲ型以出现可溶性肝抗原抗体(SLA抗体)为特征。 LKM-1抗体为自身免疫性肝炎Ⅱ型的血清













